Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Wouter den Hollander; Cindy G Boer; Deborah J Hart; Michelle S Yau; Yolande F M Ramos; Sarah Metrustry; Linda Broer; Joris Deelen; L Adrienne Cupples; Fernando Rivadeneira; Margreet Kloppenburg; Marjolein Peters; Tim D Spector; Albert Hofman; P Eline Slagboom; Rob G H H Nelissen; André G Uitterlinden; David T Felson; Ana M Valdes; Ingrid Meulenbelt; Joyce J B van Meurs

doi:10.1136/annrheumdis-2017-211214

Article info

Clinical and epidemiological research

Extended report

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Authors

Wouter den Hollander Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Cindy G Boer Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Deborah J Hart Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK PubMed articles Google scholar articles
Michelle S Yau Institute for Aging Research, Hebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USAClinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Massachusetts, USA PubMed articles Google scholar articles
Yolande F M Ramos Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Sarah Metrustry Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK PubMed articles Google scholar articles
Linda Broer Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Joris Deelen Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The NetherlandsMax Planck Institute for Biology of Ageing, Cologne, Germany PubMed articles Google scholar articles
L Adrienne Cupples Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA PubMed articles Google scholar articles
Fernando Rivadeneira Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Margreet Kloppenburg Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Marjolein Peters Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
Tim D Spector Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK PubMed articles Google scholar articles
Albert Hofman Department of Epidemiology, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA PubMed articles Google scholar articles
P Eline Slagboom Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Rob G H H Nelissen Department of Orthopedics, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
André G Uitterlinden Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The NetherlandsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles
David T Felson Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK PubMed articles Google scholar articles
Ana M Valdes School of Medicine, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Ingrid Meulenbelt Department of Medical Statistics and Bioinformatics, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Joyce J B van Meurs Department of Internal Medicine, Genetic Laboratory, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articles Google scholar articles

Correspondence to Dr Joyce J B van Meurs, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, Room Ee571, Rotterdam 3000DR, The Netherlands; j.vanmeurs{at}erasmusmc.nl

View Full Text

Citation

den Hollander W, Boer CG, Hart DJ, et al

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

Annals of the Rheumatic Diseases 2017;76:2046-2053.

Publication history

Received January 27, 2017
Revised July 20, 2017
Accepted July 31, 2017
First published August 30, 2017.

Online issue publication

April 25, 2023

Article Versions

Previous version (2 November 2019).
Previous version (2 November 2019).
You are viewing the most recent version of this article.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Main menu

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password