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Spontaneous hypertensive rat exhibits bone and meniscus phenotypes of osteoarthritis: is it an appropriate control for MetS-associated OA?
  1. PokMan Boris Chan1,
  2. Chunyi Wen2
  1. 1Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong, Hong Kong
  2. 2Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University
  1. Correspondence to Dr Chunyi Wen, Hong Kong Polytechnic University, Biomedical Engineering, ST417, Hong Kong 000000, Hong Kong; chunyi.wen{at}polyu.edu.hk

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The potential roles of metabolic syndrome (MetS) in the onset and progression of osteoarthritis (OA) have been a hot topic in the field since it may potentially open up to new non-surgical treatment regimens. To better study the relationship between MetS and OA, a suitable animal model would be a vital tool in understanding the pathomechanism and also for screening and testing various potential drug candidates.

We have recently read Deng and colleagues’ letter entitled ‘Eplerenone treatment alleviates the development of joint lesions in a new rat model of spontaneous metabolic-associated osteoarthritis’ published online this May, which mentioned the use of ‘obese spontaneously hypertensive heart failure’ (SHHFcp/cp) rat model to study MetS-associated OA and chronic administration of eplerenone, a mineralocorticoid receptor antagonist, as a treatment.1 While we appreciate the authors’ dedicated effort, we believe there are several …

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