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Response to: 'Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries' by Graver et al
  1. Francesco Ciccia1,
  2. Aroldo Rizzo2,
  3. Carlo Salvarani3,
  4. Giovanni Triolo1
  1. 1University of Palermo, Palermo, Italy
  2. 2Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy
  3. 3Arcispedale Santa Maria Nuova, Reggio Emilia, Italy
  1. Correspondence to Dr. Francesco Ciccia, Departmentof Internal Medicine, Division of Rheumatology, Piazza delle Cliniche2, 90127 Palermo, Italy; francesco.ciccia{at}

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We thank Graver et al1 for their interest in our recently published article on artery tertiary lymphoid organs (ATLOs) in giant cell arteritis (GCA).2

The authors stained temporal artery biopsies of 21 biopsy-proven GCA patients (71% female, mean duration of disease of 2.3±0.9 months) that fulfilled the 1990 American College of Rheumatology classification criteria with anti-CD20 and anti-CD3 antibodies. On the basis of this experimental approach, they confirmed the presence of ATLOs only in the adventitia of inflamed arteries of GCA patients and not in the media as demonstrated in our study. This statement, however, is not supported in our opinion by the experimental approach chosen …

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