Article Text


EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis
  1. Garifallia Sakellariou1,
  2. Philip G Conaghan2,
  3. Weiya Zhang3,
  4. Johannes W J Bijlsma4,
  5. Pernille Boyesen5,
  6. Maria Antonietta D'Agostino6,7,
  7. Michael Doherty3,
  8. Daniela Fodor8,
  9. Margreet Kloppenburg9,
  10. Falk Miese10,
  11. Esperanza Naredo11,
  12. Mark Porcheret12,
  13. Annamaria Iagnocco13
  1. 1Division of Rheumatology, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy
  2. 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute of Health Research Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK
  3. 3Academic Rheumatology, Clinical Sciences Building, University of Nottingham, Nottingham City Hospital, Nottingham, UK
  4. 4Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
  5. 5Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  6. 6APHP, Hôpital Ambroise Paré, Service de Rhumatologie, Boulogne-Billancourt, France
  7. 7INSERM U1173, Laboratoire d'Excellence INFLAMEX, Université Paris Ouest-Versailles St.-Quentin, Saint Quentin en Yvelines, France
  8. 82nd Internal Medicine Department, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
  9. 9Department of Rheumatology, Leiden University Medical Center (LUMC), Leiden, The Netherlands
  10. 10Department of Diagnostic and Interventional Radiology, Medical Faculty, University Dusseldorf, Dusseldorf, Germany
  11. 11Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain
  12. 12Research Institute for Primary Care and Health Sciences, Keele University, Keele, UK
  13. 13Rheumatology Unit, Dipartimento di Scienze Cliniche e BIologiche, Università degli Studi di Torino, Turin, Italy
  1. Correspondence to Professor Philip G Conaghan, Leeds Institute of Rheumatic and Musculoskeletal Medicine, Chapel Allerton Hospital, Leeds LS7 4SA, UK; p.conaghan{at}


The increased information provided by modern imaging has led to its more extensive use. Our aim was to develop evidence-based recommendations for the use of imaging in the clinical management of the most common arthropathy, osteoarthritis (OA). A task force (including rheumatologists, radiologists, methodologists, primary care doctors and patients) from nine countries defined 10 questions on the role of imaging in OA to support a systematic literature review (SLR). Joints of interest were the knee, hip, hand and foot; imaging modalities included conventional radiography (CR), MRI, ultrasonography, CT and nuclear medicine. PubMed and EMBASE were searched. The evidence was presented to the task force who subsequently developed the recommendations. The strength of agreement for each recommendation was assessed. 17 011 references were identified from which 390 studies were included in the SLR. Seven recommendations were produced, covering the lack of need for diagnostic imaging in patients with typical symptoms; the role of imaging in differential diagnosis; the lack of benefit in monitoring when no therapeutic modification is related, though consideration is required when unexpected clinical deterioration occurs; CR as the first-choice imaging modality; consideration of how to correctly acquire images and the role of imaging in guiding local injections. Recommendations for future research were also developed based on gaps in evidence, such as the use of imaging in identifying therapeutic targets, and demonstrating the added value of imaging. These evidence-based recommendations and related research agenda provide the basis for sensible use of imaging in routine clinical assessment of people with OA.

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Osteoarthritis (OA) is a major cause of pain and disability worldwide. Although conventional radiography (CR) is the most commonly used technique to evaluate structural features of OA, significant advances have been made in the field of imaging over the last decade, allowing a more accurate evaluation of both bone and soft-tissue abnormalities. While newer modalities such as MRI and ultrasound have increased the understanding of the multiple pathologies contributing to the OA phenotype, it is not clear how they should be used in routine care. The role of imaging in clinical practice for OA diagnosis, management and follow-up has not been clearly defined. Despite this limitation, the increased availability of modern imaging has expanded its use, with possible excesses1 leading to increased costs. A European League Against Rheumatism (EULAR) task force was therefore created to develop evidence-based recommendations on the use of imaging in the management of symptomatic, peripheral joint OA, for clinicians who treat OA in their clinical practice.


A group selected from a range of expertise (rheumatologists, radiologists, primary care physicians, methodologists and patients) and representing nine countries was included in the task force. During the first meeting, the focus of the recommendations (symptomatic OA affecting the knee, hip, hand or foot) was clarified. Clinically relevant questions on the application of imaging in OA were proposed and nine research questions were selected by consensus to guide a detailed systematic literature review (SLR). Two questions that covered the same area were subsequently combined. The areas of diagnosis, prognosis, follow-up and treatment were covered. The questions were rephrased according to the population, intervention, comparison, outcome (PICO) (see online supplementary file S1 research questions).

An SLR was performed by one of the authors (GS), with checking of all extractions by one of three other authors experienced in SLRs. The search strategies were based on both MeSh terms and free text. The searches were performed separately for each joint (see online supplementary file S2 search strategies). The titles and abstracts of the references that were retrieved were screened by the same author according to predefined inclusion and exclusion criteria, based on the PICO for each question, and potentially relevant articles were evaluated in their full text. Studies in English including adults (≥18) with symptomatic OA of the knee, hip, hand and foot were eligible for inclusion. Imaging modalities included were CR, MRI, ultrasonography (US), CT and nuclear medicine techniques (scintigraphy, positron emission tomography). Randomised controlled trials (RCTs), systematic reviews and meta-analyses, controlled clinical trials, case–control studies, cross-sectional studies and cohort studies were eligible for inclusion. Studies had to examine the role of imaging in the following: in making a diagnosis of OA; in detecting OA elementary lesions; for differential diagnosis; in the management of OA; in predicting outcome and therapeutic response; for follow-up of disease course and to guide treatment. The same articles could be included in more than one search. Due to the variety of joint sites and imaging and the expectation of a strong degree of heterogeneity across studies, meta-analyses were not prespecified before study selection and extraction. The methodological quality of the included studies was not assessed by quality scores, but some aspects were considered for all studies, together with design-specific indicators. For all studies, study design, sample size and setting sampling were considered. For RCTs allocation concealment, drop-out rate as well as the presence of funding, for diagnostic studies the adequacy of the reference standard and for cohort studies the presence of adjustment for confounders were also evaluated. Each aspect was evaluated separately as leading to high, low or unclear risk of bias.

During the second meeting, the results of the literature review were presented and the experts developed ‘over-arching’ statements (background statements to preface the recommendations) and drafted seven recommendations through a process of discussion and consensus. The number of recommendations emerged through the discussion after the presentation of the literature. To explore the presence of additional evidence concerning two recommendations, two more research questions on (1) the different performance of various radiographic views in detecting OA features and (2) the accuracy of imaging-guided compared with blind joint injections were added to the original eight, with two additional literature searches (see online supplementary file S1, research questions and S2, search strategies). After evaluation of these results, the Task Force confirmed the final wording of the recommendations and scored the perceived level of agreement (LOA) for each statement using a 0–10 numeric rating scale (0=fully disagree; 10=fully agree), reflecting both literature evidence and expert opinion. Recommendations for further research were then developed based on gaps in the SLRs.


The searches in the electronic databases (PubMed, EMBASE) were performed up to the end of January 2015 for the main searches and December 2015 for the additional searches. The initial search resulted in 6858 records (615 duplicates). Of the remaining 6243 articles, 4926 were excluded based on the title and abstracts, leaving 1317 articles for detailed review. All full-text articles were retrieved, 986 articles were excluded after reviewing the full text, leaving 331 articles for inclusion (see online supplementary file S3). The hand search of the references of the included studies identified 33 additional articles, leading to a total of 364 studies finally analysed. Articles that were relevant to more than one research question were used for each question as appropriate. The number of articles included for each site and imaging is shown in online supplementary figure S4. The complete results of the SLR with references are reported in the online supplementary file S5.

The additional search on the comparison of different radiographic views resulted in 4774 articles (225 duplicates). Of the remaining 4549, 4496 were excluded based on the title and abstracts, leaving 53 articles for detailed review. Twenty-three articles were excluded after reviewing the full text, leaving 30 articles for inclusion. The hand search identified one additional article for inclusion, leading to a total of 31 articles finally included (see online supplementary file S6).

The additional search on the added value of imaging to guide intra-articular procedures resulted in 5379 articles (834 duplicates). Of the remaining 4545, 4520 were excluded based on the title and abstracts, leaving 25 articles for detailed review. Nineteen articles were excluded after reviewing the full text, leaving six articles for inclusion. The hand search identified two additional articles for inclusion, leading to a total of eight articles finally included (see online supplementary file S7). The complete results of the additional searches with references are reported in the online supplementary file S8.


Table 1 summarises the seven recommendations with their corresponding level of evidence and LOA. Each recommendation is presented in detail below.

Table 1

Recommendations, levels of evidence and level of agreement (LOA)

Overarching statements

  1. These recommendations pertain only to symptomatic OA.

  2. Imaging abnormalities of OA are commonly seen especially with increasing age.

  3. Joint symptoms are also common and increase with age. Symptoms are not always causally related to imaging abnormalities.

  4. Full history and examination is always required before considering the need for investigations, including imaging.

  5. Modern imaging modalities provide the capability to detect a wide range of soft tissue, bony and cartilage pathology in OA. However, the increased information provided has not yet had any influence on clinical decision-making with respect to management.

Making a diagnosis of OA

Recommendation 1: Imaging is not required to make the diagnosis in patients with typical[i] presentation of OA.

Level of evidence: III–IV. LOA (95% CI) 8.7 (7.9 to 9.4)

Although many studies applied imaging for diagnostic purposes, there was a lack of studies in which imaging was applied in addition to clinical findings to evaluate its additional impact on the certainty of diagnosis, which was a predefined criterion for inclusion.

A single study examined the added value of US of hand and feet over clinical findings in a cohort of patients with suspected or confirmed arthritis. When US was added to clinical findings, the diagnostic confidence in differentiating OA from inflammatory arthritis significantly increased.2 Due to the absence of strong evidence supporting the use of different imaging modalities at different anatomical sites, the systematic use of imaging in the diagnostic process was not recommended in cases with typical clinical presentation. However, based on the joint site and clinical presentation, imaging might be considered when diagnoses other than OA are suspected. This aspect has been taken into account in Recommendation 2.

Recommendation 2: In atypical presentations, imaging is recommended to help confirm the diagnosis of OA and/or make alternative or additional diagnoses. Level of evidence: IV. LOA (95% CI) 9.6 (9.1 to 10)

Studies were eligible for inclusion if they investigated the added value of imaging for differential diagnosis over clinical evaluation. Among studies evaluating the application of imaging for differential diagnosis, no study evaluated the impact of the addition of imaging above clinical findings. The possible application if imaging in atypical clinical scenarios was however recognised by the experts, which included this point in the recommendation.

Monitoring disease

Recommendation 3: Routine imaging in OA follow-up is not recommended. However, imaging is recommended if there is unexpected rapid progression of symptoms or change in clinical characteristics to determine if this relates to OA severity or an additional diagnosis. Level of evidence: III–IV. LOA (mean, 95% CI) 8.8 (7.9 to 9.7)

A specific question addressed the use of imaging for the follow-up. The 117 studies (mostly cohort studies) retrieved covered all joint sites except the foot and all imaging modalities except CT (see online supplementary figure S9). Most of the 83 included studies focused on sensitivity to change.3–86 The remaining studies investigated the trajectories of changes of elementary lesions detected by imaging when following OA natural history or described the parallel changes between different abnormalities detected by different imaging modalities.40 ,51 ,53 ,87–101 Only a minority of studies examined the correlation between the change in imaging features and symptoms or relevant clinical outcomes (table 2) and only four US studies evaluated the change of imaging after treatment (see online supplementary file S10).102–111

Table 2

Studies correlating changes in imaging findings with symptoms, function or clinical outcome

Moreover, there were no studies comparing clinical follow-up with imaging follow-up or strategies adding imaging to clinical management.

The impact of imaging in the management of OA was also specifically addressed by the literature search. Three studies addressed this point. One RCT evaluating the impact of MRI in patients with knee pain assessed in a general practice setting showed that MRI led to an increase in therapeutic confidence but no significant changes in management.112 A cross-sectional study in an orthopaedic setting investigating the impact of CR over management decisions in knee OA showed that CR led to the change in the opinion in 166/400 cases.113 A similar study evaluating the impact of CR in the assignment of priority for surgery in hip OA showed a relative risk (95% CI) of 1.98 (1.23 to 3.19) for an earlier assignment in patients with more severe radiographic scores.114 No studies evaluated the impact of imaging for the management of hand or foot OA and no studies specifically addressed the issue of non-surgical management.

Recommendation 4: If imaging is needed, conventional (plain) radiography should be used before other modalities. To make additional diagnoses, soft tissues are best imaged by US or MRI and bone by CT or MRI. Level of evidence: III–IV. LOA (95% CI) 8.7 (7.9 to 9.6)

The performance of imaging in the detection of OA elementary lesions was addressed by the SLR and highlighted heterogeneity in the use of imaging modality, lesions considered and reference standard. In fact, physical examination was frequently taken into account as reference standard, while surgery was considered in a minority of studies. Online supplementary file S11 summarises the studies with surgery as the reference standard.115–136 As expected, the use of CR was mainly to detect bone and indirectly cartilage loss, MRI was used for bone, cartilage and soft tissues, with a single study assessing US for the evaluation of cartilage.

In general, CR was the imaging modality that was most frequently used for diagnostic, prognostic and follow-up purposes. However, no studies of the cost-effectiveness of each imaging modality or their sequence were found. In the absence of appropriate literature, the experts decided to emphasise the role of the most easily available and less costly imaging modality, proposing as second-level investigations techniques that, due to their characteristics, are more suitable for the detailed assessment of soft tissues (MRI and US) or bone (CT).

Recommendation 5: Consideration of radiographic views is important for optimising detection of OA features; in particular for the knee, weightbearing and patellofemoral views are recommended. Level of evidence: III. LOA (95% CI) 9.4 (8.7 to 9.9)

This topic was addressed by an additional research question, evaluating the optimal combination of radiographic views in OA. Twenty-seven studies comparing different views for knee OA were included. In this context, all studies involving the tibiofemoral compartment considered weightbearing views, both in extension and various degrees of flexion.7 ,8 ,10 ,17 ,25 ,118 ,123 ,137–147 Studies comparing fully extended and flexed views in general showed a moderate to good agreement between the two projections and similar sensitivity and specificity in detecting cartilage damage, considering arthroscopic findings as reference.117 ,138 ,139 ,148 ,149 The flexed views demonstrated superiority in detecting joint space narrowing, a greater sensitivity to change and reproducibility compared with extended views.8 ,17 ,140 ,141 ,143 ,144

Concerning the assessment of the patellofemoral compartment, skyline views had a greater inter-reader and intra-reader reliability and sensitivity to change compared with lateral projections.24 ,143 ,144 ,149 With surgery as reference standard, the skyline view had greater sensitivity and specificity to detect cartilage damage at the patellofemoral joint.150

There were five studies assessing the hip. Three studies compared weightbearing and supine anteroposterior (AP) views of the pelvis, one of them showing greater average and maximal joint space width detected by the weightbearing view, the remaining showing inconsistent results.151–155 Two studies comparing pelvis, hip and oblique views projections in terms of reliability and sensitivity to change demonstrated similar reliability for views dedicated to the hip and views including all the pelvis, with comparable sensitivity to change.72 ,75 No studies assessing the hand and the foot were found.

Role in prognosis

Recommendation 6: According to current evidence, imaging features do not predict non-surgical treatment response and imaging cannot be recommended for this purpose. Level of evidence: II–III. LOA (95% CI) 8.7 (7.5 to 9.7)

Two specific research questions addressed the role of imaging in prognosis, referring to both the prediction of the natural history and to the prediction of non-surgical treatment outcomes. A number of studies addressed the issue of the prognostic value of imaging as predictor of the natural history of OA (see online supplementary figure S12), while only a minority of studies, evaluating all joint sites, investigated the role in predicting treatment response. Due to the heterogeneity in populations, interventions, treatment and study design, a meta-analysis was not possible. In addition, progression of some imaging pathologies may have limited clinical significance. Tables 3 and 4 summarise the results of the 28 primary studies in which imaging was applied to predict treatment response.14 ,84 ,156–176 Moreover, an existing SLR was available, without a quantitative synthesis.177 The results on the prediction of response were mostly inconsistent across studies; for this reason the use of imaging for this purpose was not recommended.

Table 3

Summary of studies evaluating imaging in the prediction of response to treatment: systemic treatment

Table 4

Summary of studies evaluating imaging in the prediction of response to treatment: intra-articular treatment

Treatment (imaging-guided procedures)

Recommendation 7: The accuracy of intra-articular injection depends on the joint and on the skills of the practitioner and imaging may improve accuracy. Imaging is particularly recommended for joints that are difficult to access due to factors including site (eg, hip), degree of deformity and obesity. Level of evidence: III–IV. LOA (95% CI) 9.4 (8.9 to 9.9)

A search addressing the impact of imaging to guide intra-articular injections was run specifically for OA in the beginning. Including only studies comparing imaging-guided to blind procedures, four primary studies were found for the knee and one for the hand, and a qualitative SLR for the knee (table 5). The added value of US was addressed by four studies, while fluoroscopic guidance was tested in a single study.179–183

Table 5

Studies comparing imaging-guided to blind injections in OA

In order to retrieve further information on this topic, an additional search was performed (see online supplementary file S1 for search strategies), including studies comparing blind to guided injections in OA and also in other conditions. This search found eight studies, of which three were already included in the previous results (see online supplementary file S13).184–188 Most of the studies were focused on the knee, with some studies on the hand and the foot, while no studies were found for the hip. All the additional studies investigated the impact of US. Accuracy was found to be better in imaging guided compared with blind procedures; however, the results on the clinical outcomes of the injection were less consistent across studies. For these reasons, the systematic use of imaging to drive injections was not recommended, leaving this tool to drive injection in specific situations, identified by the experts. Although the imaging modality is not specified in the recommendation, there is published evidence for the use of US, and imaging allows for real-time evaluation of injection placement.

Future research agenda

The most important topics to drive future research were selected by the Task Force based on the (often considerable) gaps in the evidence and the needs arising from clinical practice (table 6).

Table 6

Future research agenda


Although a number of recommendations have been made on how to use imaging in OA clinical trials, these are the first recommendations on the use of imaging in OA in clinical practice. The development of the recommendations started from questions of clinical relevance selected by a task force of experts, with the aim to focus on topics of interest for clinical practice rather than research. The literature review identified a large number of studies, covering most joint sites. However, a possible limitation of this work is that we used a search term of ‘osteoarthritis’ and not ‘pain’, and it is possible we missed studies that imaged painful sites without specifically mentioning OA; this may explain the paucity of foot pain studies included. Although CR was still the most frequently applied technique, a substantial number of studies focused on modern imaging, MRI and US in particular.

However, despite the amount of data available in the literature, only a small part of this information was relevant for clinical practice. For this reason, many areas needing further investigation were identified. In particular, there was a lack of strategic studies investigating the additional value of imaging over clinical findings in making a diagnosis of OA, in the management and the follow-up of the disease, and inconsistent results dealing with the prediction of the outcome of non-pharmacological treatments. The absence of good study information in these areas did not enable the Task Force to recommend systematic imaging in all these areas. A research agenda was therefore generated in order to address these topics in the future research.

In conclusion, seven recommendations covering different areas in the routine management of OA were developed. These are based on both available scientific evidence and expert opinion to provide a valuable and sensible guide for the use of imaging in clinical practice.


The authors thank Mrs Jaqueline Mäder for participating to the development of the recommendations.


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  • GS and PGC contributed equally.

  • Contributors GS and PGC contributed equally. GS performed the literature review, GS and PGC produced drafts of the manuscript with advice from AI and WZ. All authors were involved in the production of the recommendations and have reviewed the final manuscript.

  • Funding The authors would like to thank EULAR for financial support for this work. PGC is supported in part by the National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit.

  • Disclaimer The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • i Typical features include usage-related pain, short duration morning stiffness, age >40, symptoms affecting one or a few joints.

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