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Why CAPS criteria are not diagnostic criteria?
  1. Robert BM Landewé1,2,
  2. Désirée MFM van der Heijde3,4
  1. 1Department of Rheumatology & Clinical Immunology, Amsterdam Rheumatology & immunology Center, Amsterdam, The Netherlands
  2. 2Department of Rheumatology, Zuyderland Medical Center, Heerlen, The Netherlands
  3. 3Deprtament of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  4. 4Diakonhjemmet Hospital, Oslo, Norway
  1. Correspondence to Professor Robert BM Landewé, Department of Rheumatology , Zuyderland Medical Center, Heerlen 6311PP, The Netherlands; landewe{at}rlandewe.nl

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Kuemmerle-Deschner et al1 have recently published diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).

CAPS encompasses a group of very rare disorders with incompletely understood pathogenesis and diverse clinical presentations. The authors justify their efforts by claiming that there is a significant delay in diagnosis, which, in their opinion, is due to the lack of recognition and clear diagnostic criteria.

While the authors should be commended for their rigorous work, they may have overlooked the fact that they have developed classification criteria rather than diagnostic criteria. Recently, Aggarwall et al2 have pointed out the fundamental concerns related to …

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