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Correspondence
Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion
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  1. Yan-Fang Xing1,
  2. Yu-Qi Zhou2,
  3. Guo-Wei Ma3,
  4. Ding-Yun Feng2,
  5. Xiu-Rong Cai4,
  6. Xing Li4
  1. 1Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China
  2. 2Department of Respiration, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China
  3. 3Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China
  4. 4Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China
  1. Correspondence to Dr Xing Li, Department of Medical Oncology, The Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Road, Guangzhou 510630, China; lixing9{at}mail.sysu.edu.cn

https://doi.org/10.1136/annrheumdis-2016-209786

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    We read with great interest the article ‘Myeloid-derived suppressor cells have a proinflammatory role in the pathogenesis of autoimmune arthritis’ by Chunqing Guo et al.1 In this paper, the authors used anti-Gr1 antibody to deplete myeloid-derived suppressor cells (MDSCs) in arthritic mice and they found that it reduced disease severity and Th17 response. However, they did not report the efficiency of MDSC depletion.

    Anti-Gr1 antibody (RB6-8C5) was widely used and considered to be effective in eliminating MDSC. Srivastava et al2 found that anti-Gr1 antibody led to …

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