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Factors associated with change in radiographic damage scores in gout: a prospective observational study
  1. Alastair Eason1,
  2. Meaghan E House2,
  3. Zoe Vincent2,
  4. Julie Knight2,
  5. Paul Tan2,
  6. Anne Horne2,
  7. Gregory D Gamble2,
  8. Anthony J Doyle3,
  9. William J Taylor4,
  10. Nicola Dalbeth2
  1. 1Department of Radiology, Auckland District Health Board, Auckland, New Zealand
  2. 2Department of Medicine, University of Auckland, Auckland, New Zealand
  3. 3Radiology with Anatomy, University of Auckland, Auckland, New Zealand
  4. 4Department of Medicine, University of Otago, Wellington, New Zealand
  1. Correspondence to Professor Nicola Dalbeth, Bone and Joint Research Group, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd, Grafton, Auckland 1023, New Zealand; n.dalbeth{at}


Background/aims Radiographic damage is frequently observed in patients with longstanding gout. The aim of this prospective observational study was to determine factors associated with change in radiographic damage scores in gout.

Methods People with gout and disease duration <10 years were recruited into this prospective observational study. At the baseline visit, structured assessment was undertaken in 290 participants including detailed clinical examination and plain radiographs (XR) of the hands and feet. Participants were invited to attend a further study visit with repeat XR 3 years after the baseline visit. XR were scored for erosion and joint space narrowing according to the gout-modified Sharp/van der Heijde XR damage score.

Results Age, subcutaneous tophus count and tender joint count were independently associated with XR damage score at the baseline visit. Paired serial XR were available for 140 participants. In stepwise linear regression analysis, change in total damage score over 3 years was positively associated with change in subcutaneous tophus count and baseline XR damage score, and inversely associated with baseline subcutaneous tophus count (model R2=0.39, p<0.001). Change in subcutaneous tophus count contributed most to the change in erosion score (partial R2 change=0.31, p<0.001), and baseline XR damage score contributed most to the change in narrowing score (partial R2 change=0.31, p<0.001).

Conclusions Development of new subcutaneous tophi and baseline radiographic damage are associated with progressive joint damage scores in people with gout. These data provide further evidence that the tophus plays a central role in bone erosion in gout.

  • Gout
  • Arthritis
  • Chondrocytes

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