Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis

Toby O Smith; Kun Zou; Natasya Abdullah; Xi Chen; Sarah R Kingsbury; Michael Doherty; Weiya Zhang; Philip G Conaghan

doi:10.1136/annrheumdis-2015-208823

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Clinical and epidemiological research

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Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis

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Toby O Smith Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, UK PubMed articles Google scholar articles
Kun Zou Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology, Sichuan, China PubMed articles Google scholar articles
Natasya Abdullah Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Xi Chen Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Sarah R Kingsbury Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK PubMed articles Google scholar articles
Michael Doherty Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Weiya Zhang Faculty of Medicine & Health Sciences, University of Nottingham, Nottingham, UK PubMed articles Google scholar articles
Philip G Conaghan Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK PubMed articles Google scholar articles

Correspondence to Professor Philip G Conaghan, NIHR Leeds Musculoskeletal Biomedical Research Unit, Section of Musculoskeletal Disease, Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, UK; p.conaghan{at}leeds.ac.uk

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Citation

Smith TO, Zou K, Abdullah N, et al

Does flare trial design affect the effect size of non-steroidal anti-inflammatory drugs in symptomatic osteoarthritis? A systematic review and meta-analysis

Annals of the Rheumatic Diseases 2016;75:1971-1978.

Publication history

Received October 26, 2015
Revised December 28, 2015
Accepted January 23, 2016
First published February 16, 2016.

Online issue publication

February 02, 2019

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