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The recent interest for interleukin-33 (IL-33) in primary Sjögren syndrome (pSS) pathophysiology is due to three studies,1–3 which have shown an increase in IL-33 serum levels in patients with pSS compared with controls. IL-33 is a member of the IL-1 family which is released in case of cellular damage and acts as an alarmin; however, its role in pSS physiopathology remains unclear.
In the present study, we aimed to replicate the association described between IL-33 serum level and pSS diagnosis. For that purpose, we used Quantikine and Duoset ELISA (R&D Systems, Minnesota, USA) and Luminex (Milliplex HTh17, Merck, Darmstadt, Germany). The Quantikine and Luminex kits are validated for serum samples, while the Duoset is only validated for use with culture supernates (data from R&D). IL-33 serum levels were assessed in patients with pSS from the French multicentre prospective ASSESS cohort (Assessment of Systemic Signs and Evolution in Sjögren Syndrome, principal investigator: X …