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Disease activity is longitudinally related to sacroiliac inflammation on MRI in male patients with axial spondyloarthritis: 2-years of the DESIR cohort
  1. Victoria Navarro-Compán1,2,
  2. Sofia Ramiro1,
  3. Robert Landewé3,4,
  4. Maxime Dougados5,
  5. Corinne Miceli-Richard6,
  6. Pascal Richette7,8,
  7. Désirée van der Heijde1
  1. 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Department of Rheumatology, University Hospital La Paz, IdiPaz, Madrid, Spain
  3. 3Department of Clinical Immunology & Rheumatology, Amsterdam Rheumatology & Clinical Immunology Center, University of Amsterdam, Amsterdam, The Netherlands
  4. 4Department of Rheumatology, Atrium Medical Center, Heerlen, The Netherlands
  5. 5Department of Rheumatology, Paris Descartes University, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, INSERM: Clinical Epidemiology and Biostatistics, PRES Sorbonne Paris-Cité, Paris, France
  6. 6Department of Rheumatology, Hôpitaux Universitaires Paris-Sud, France
  7. 7Université Paris Diderot, UFR médicale, Paris, France; APHP Hôpital Lariboisiére, Fédération de Rhumatologie, Paris, France
  8. 8Inserm U1132, Hôpital Lariboisière, Paris, France
  1. Correspondence to Dr Victoria Navarro-Compán, Department of Rheumatology, Leiden University Medical Center, PO Box 9600, Leiden 2300 RC, The Netherlands; mvictoria.navarroc{at}gmail.com

Abstract

Objectives To investigate the longitudinal relationship between inflammatory lesions in sacroiliac joints on MRI (MRI-SI) and clinical disease activity measures (DA) in patients with axial spondyloarthritis (axSpA).

Methods Two-year follow-up data from 167 patients (50% males, mean (SD) age 33 (9) years) fulfilling the Assessment of SpondyloArthritis international Society axSpA criteria in the DEvenir des Spondylarthopathies Indifférenciées Récentes cohort with MRI-SI at baseline, 1 year and 2 years were analysed. The relationship between MRI-SI (as dependent variable) and DA (Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), patient's global DA, night pain, C reactive protein and erythrocyte sedimentation rate, as independent variables) was investigated using two types of generalised estimating equations (GEE) models: model of absolute scores and model of change scores.

Results In the model of absolute scores, the relationship between DA and MRI-SI was different for males and females: in males, but not in females, a statistically significant relationship with MRI-SI was found for all DA except BASDAI. In the model of changes, only ASDAS (beta (95% CI): 2.79 (0.85 to 4.73) and pain at night (0.97 (0.04 to 1.90)) were significantly associated in males while again in females no significant relationship was found. ASDAS fitted the data best.

Conclusions In male patients, but not in female patients, with axSpA, clinical DA, especially if measured by ASDAS, is longitudinally associated with MRI-SI inflammatory lesions.

  • Spondyloarthritis
  • Ankylosing Spondylitis
  • Inflammation

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