Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway

Elena López-Isac; Diana Campillo-Davo; Lara Bossini-Castillo; Sandra G Guerra; Shervin Assassi; Carmen Pilar Simeón; Patricia Carreira; Norberto Ortego-Centeno; Paloma García de la Peña; the Spanish Scleroderma Group; Lorenzo Beretta; Alessandro Santaniello; Chiara Bellocchi; Claudio Lunardi; Gianluca Moroncini; Armando Gabrielli; Gabriela Riemekasten; Torsten Witte; Nicolas Hunzelmann; Alexander Kreuter; Jörg HW Distler; Alexandre E Voskuyl; Jeska de Vries-Bouwstra; Ariane Herrick; Jane Worthington; Christopher P Denton; Carmen Fonseca; Timothy RDJ Radstake; Maureen D Mayes; Javier Martín

doi:10.1136/annrheumdis-2015-208154

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Basic and translational research

Extended report

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway

Authors

Elena López-Isac Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain PubMed articles Google scholar articles
Diana Campillo-Davo Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain PubMed articles Google scholar articles
Lara Bossini-Castillo Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain PubMed articles Google scholar articles
Sandra G Guerra Centre for Rheumatology, Royal Free and University College Medical School, London, UK PubMed articles Google scholar articles
Shervin Assassi Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center–Houston, Houston, USA PubMed articles Google scholar articles
Carmen Pilar Simeón Department of Internal Medicine, Valle de Hebrón Hospital, Barcelona, Spain PubMed articles Google scholar articles
Patricia Carreira Department of Rheumatology, 12 de Octubre University Hospital, Madrid, Spain PubMed articles Google scholar articles
Norberto Ortego-Centeno Department of Internal Medicine, Clinic University Hospital, Granada, Spain PubMed articles Google scholar articles
Paloma García de la Peña Department of Rheumatology, Madrid Norte Sanchinarro Hospital, Madrid, Spain PubMed articles Google scholar articles
the Spanish Scleroderma Group
Google scholar articles
Lorenzo Beretta Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy PubMed articles Google scholar articles
Alessandro Santaniello Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy PubMed articles Google scholar articles
Chiara Bellocchi Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy PubMed articles Google scholar articles
Claudio Lunardi Department of Medicine, Università degli Studi di Verona, Verona, Italy PubMed articles Google scholar articles
Gianluca Moroncini Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche and Ospedali Riuniti, Ancona, Italy PubMed articles Google scholar articles
Armando Gabrielli Clinica Medica, Dipartimento di Scienze Cliniche e Molecolari, Università Politecnica delle Marche and Ospedali Riuniti, Ancona, Italy PubMed articles Google scholar articles
Gabriela Riemekasten Department of Rheumatology and Clinical Immunology, Charité University Hospital, Berlin, Germany German Rheumatism Research Center (DRFZ), a Leibniz Institute, Berlin, Germany PubMed articles Google scholar articles
Torsten Witte Department of Clinical Immunology, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Nicolas Hunzelmann Department of Dermatology, University of Cologne, Cologne, Germany PubMed articles Google scholar articles
Alexander Kreuter Department of Dermatology, Venereology, and Allergology, HELIOS St Elisabeth Hospital Oberhausen, Germany PubMed articles Google scholar articles
Jörg HW Distler Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany PubMed articles Google scholar articles
Alexandre E Voskuyl Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands PubMed articles Google scholar articles
Jeska de Vries-Bouwstra Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands PubMed articles Google scholar articles
Ariane Herrick Centre for Musculoskeletal Research and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles
Jane Worthington Centre for Musculoskeletal Research and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles
Christopher P Denton Centre for Rheumatology, Royal Free and University College Medical School, London, UK PubMed articles Google scholar articles
Carmen Fonseca Centre for Rheumatology, Royal Free and University College Medical School, London, UK PubMed articles Google scholar articles
Timothy RDJ Radstake Department of Rheumatology & Clinical Immunology, Laboratory of Translational Immunology, department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands PubMed articles Google scholar articles
Maureen D Mayes Division of Rheumatology and Clinical Immunogenetics, The University of Texas Health Science Center–Houston, Houston, USA PubMed articles Google scholar articles
Javier Martín Institute of Parasitology and Biomedicine López-Neyra, IPBLN-CSIC, PTS Granada, Granada, Spain PubMed articles Google scholar articles

Correspondence to Dr Javier Martin, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC. Parque Tecnológico Ciencias de la Salud. Avenida del Conocimiento s/n Armilla (Granada) 18016, Spain; martin{at}ipb.csic.es

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Citation

López-Isac E, Campillo-Davo D, Bossini-Castillo L, et al

Influence of TYK2 in systemic sclerosis susceptibility: a new locus in the IL-12 pathway

Annals of the Rheumatic Diseases 2016;75:1521-1526.

Publication history

Received June 29, 2015
Revised July 27, 2015
Accepted August 13, 2015
First published September 2, 2015.

Online issue publication

February 19, 2018

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