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  • Response to: ‘Does it make sense to investigate whether the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain?’ by Lei et al

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Correspondence response
Response to: ‘Does it make sense to investigate whether the offspring of people with a total knee replacement for severe primary knee osteoarthritis have a higher risk of worsening knee pain?’ by Lei et al
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  1. Feng Pan1,
  2. Changhai Ding1,
  3. Tania Winzenberg1,
  4. Hussain Khan1,
  5. Johanne Martel-Pelletier2,
  6. Jean-Pierre Pelletier2,
  7. Flavia Cicuttini3,
  8. Graeme Jones1
  1. 1Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia
  2. 2Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada
  3. 3Department of Epidemiology and Preventive Medicine, Monash University Medical School, Melbourne, Australia
  1. Correspondence to Dr Graeme Jones, Menzies Research Institute Tasmania, University of Tasmania, Private Bag 23, Hobart, TAS 7000, Australia; Graeme.Jones{at}utas.edu.au

https://doi.org/10.1136/annrheumdis-2015-207620

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    We would like to thank Lei et al1 for their interest in and comments on our paper on the higher risk of worsening knee pain in the offspring with a family history of knee osteoarthritis (OA) as compared with control with no family history.2

    First, we agree that the correlation between the radiographic OA and the presence of pain is weak and not significant in this cohort. Our group has published much of the research on this area and what does contribute to pain. Our contention is that radiographic OA is of limited significance and papers from this cohort show that. The MRI scans show many structural changes within the knee long before radiographic OA develops and these are …

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