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Clinical and epidemiological research
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On the HUNT for cardiovascular risk factors and disease in patients with psoriatic arthritis: population-based data from the Nord-Trøndelag Health Study
  1. Agnete Malm Gulati1,2,
  2. Anne Grete Semb3,
  3. Silvia Rollefstad3,
  4. Pål R Romundstad4,
  5. Arthur Kavanaugh5,
  6. Sasha Gulati2,6,7,
  7. Glenn Haugeberg2,8,
  8. Mari Hoff1,4
  1. 1Department of Rheumatology, St. Olavs Hospital, Trondheim, Norway
  2. 2Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway
  3. 3Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
  4. 4Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
  5. 5Department of Rheumatology, Allergy and Immunology, University of California San Diego, San Diego, California, USA
  6. 6Department of Neurosurgery, St. Olavs Hospital, Trondheim, Norway
  7. 7Norwegian Centre of Competence in Deep Brain Stimulation for Movement Disorders, Trondheim, Norway
  8. 8Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway
  1. Correspondence to Dr Agnete Malm Gulati, Department of Rheumatology, St. Olavs Hospital, Trondheim 7006, Norway; agnete.malm.gulati{at}hotmail.no

Abstract

Objective To compare the presence of cardiovascular (CV) risk factors and established CV disease in patients with psoriatic arthritis (PsA) and the general population and to compare the 10-year risk of a fatal CV event calculated by the Systematic Coronary Risk Evaluation (SCORE) algorithm.

Methods Patients with PsA (n=338) and controls (n=50 468) were recruited from the Nord-Trøndelag Health Study 3. Age-adjusted and sex-adjusted prevalence rates of CV risk factors and comorbidity were calculated and the SCORE algorithm was applied.

Results There was an increased prevalence of angina pectoris (5.0% vs 3.6%, p=0.01), history of percutaneous coronary intervention (2.4% vs 1.4%, p=0.04), hypertension (45.3% vs 39.3%, p=0.01), obesity (32.0% vs 22.4%) and tobacco smoking (21.3% vs 16.4%, p=0.02) in patients with PsA compared with controls. Patients with PsA had elevated levels of C reactive protein (CRP; p<0.001), body mass index (BMI; p<0.001) and triglycerides (p=0.01). The median calculated CV risk in patients with PsA was low and comparable with controls (0.87 vs 0.83, p=0.24). The distribution across CV risk classes was similar among patients with PsA and controls.

Conclusions Patients with PsA have a higher risk of CV disease than the background population, although there was no difference between groups in 10-year risk of a fatal CV event estimated by SCORE. However, patients with PsA had elevated levels of CV risk factors not included in the SCORE algorithm, such as BMI, triglycerides and CRP.

  • Arthritis
  • Psoriatic Arthritis
  • Cardiovascular Disease
  • Epidemiology

https://doi.org/10.1136/annrheumdis-2014-206824

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