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Evaluation of blood perfusion by laser speckle contrast analysis in different areas of hands and face in patients with systemic sclerosis
  1. A Sulli,
  2. B Ruaro,
  3. M Cutolo
  1. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
  1. Correspondence to Professor Maurizio Cutolo, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Viale Benedetto XV, n° 6, Genova 16132, Italy; mcutolo{at}unige.it

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Dear Sir,

Laser speckle contrast analysis (LASCA) is a new safe technique to quantify blood perfusion (BP) at different body areas. While several techniques have been used in systemic sclerosis (SSc) to evaluate BP at the level of hands with quite reproducible and similar results, limited information is available about BP at other specific body sites that may be affected by Raynaud's phenomenon, like nose.1–5

We assessed by LASCA (Pericam PSI, Perimed) BP in different skin areas of hands and face in patients with SSc in comparison with healthy subjects.3 ,6 ,7 After scan acquisition, regions of interest (ROIs) were created at central area of fingertips and periungual areas from II to V finger bilaterally, palm and dorsum of both hands, as well as at the level of the face (forehead, tip of nose, zygomas and perioral region) (see figure 1). BP was recorded as perfusion units (PU).

Figure 1

Regions of interest (see white open circles) for evaluation of blood perfusion (BP) by Laser Speckle …

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