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Are autoantibodies to RNA-polymerase III to be incorporated in routine diagnostic laboratory algorithms for systemic autoimmune rheumatic diseases?
  1. Jan Damoiseaux
  1. Correspondence to Dr Jan Damoiseaux, Central Diagnostic Laboratory, Maastricht University Medical Center, P. Debyelaan 25, Maastricht 6229 HX, The Netherlands; jan.damoiseaux{at}mumc.nl

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Recently a collaborative initiative of the American College of Rheumatology and the European League against Rheumatism resulted in novel classification criteria for systemic sclerosis (SSc).1 These criteria were first selected in a derivation cohort and, next, confirmed in a validation cohort. From a laboratory perspective it is interesting that the new criteria include, besides the classical anticentromere and antitopoisomerase I antibodies, also the anti-RNA polymerase III antibodies (ARA). These ARA have been associated with diffuse cutaneous involvement and …

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