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Recently a collaborative initiative of the American College of Rheumatology and the European League against Rheumatism resulted in novel classification criteria for systemic sclerosis (SSc).1 These criteria were first selected in a derivation cohort and, next, confirmed in a validation cohort. From a laboratory perspective it is interesting that the new criteria include, besides the classical anticentromere and antitopoisomerase I antibodies, also the anti-RNA polymerase III antibodies (ARA). These ARA have been associated with diffuse cutaneous involvement and …
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