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The influence of inflammation in the development of subclinical atherosclerosis in psoriatic arthritis: comment on ‘Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review’ by Jamnistki et al
  1. Miguel A González-Gay1,
  2. Carlos González-Juanatey2,
  3. Javier Llorca3,
  4. Santos Castañeda4
  1. 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Cantabria, Spain
  2. 2Cardiology Division, Hospital Universitario Lucus Augusti, Lugo, Spain
  3. 3Department of Computational Biology, School of Medicine, University of Cantabria, IFIMAV, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Cantabria, Spain
  4. 4Department of Rheumatology, Hospital de La Princesa, IIS-Princesa, Universidad Autónoma de Madrid (UAM), Madrid, Spain
  1. Correspondence to Dr Miguel A Gonzalez-Gay, Hospital Universitario Marqués de Valdecilla, IFIMAV, Avenida de Valdecilla, s/n, Santander, Cantabria 39008, Spain; miguelaggay{at}hotmail.com

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We read with great interest the elegant systematic review on cardiovascular (CV) comorbidities by Jamnitski et al, in patients with psoriatic arthritis (PsA) published in the February 2013 issue of ARD.1 Overall, we agree that there is an increased CV risk in patients with PsA similar to that observed in patients with rheumatoid arthritis (RA).2 Therefore, adequate CV risk stratification is also required in PsA patients.

The authors confirmed that subclinical atherosclerosis and CV risk factors are increased in patients with PsA when compared with controls.1 It is well known that inflammation promotes endothelial cell activation in patients with chronic inflammatory rheumatic diseases like RA.3 The presence of a chronic inflammatory state is responsible for the development of subclinical atherosclerosis and increased incidence of CV events …

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