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Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial
  1. J-Y Reginster
  1. Correspondence to Professor J-Y Reginster, Bone and Cartilage Metabolism Unit, CHU Centre Ville, Unite dExploration du Metabolisme Osseux, Liège 4020, Belgium; jyreginster{at}ulg.ac.be

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I would like to reply to the recent letter by Murphy et al1 regarding the possible influence of obesity and weight changes on the results of the Strontium ranelate Efficacy in Knee Osteoarthritis trIAl (SEKOIA) trial of the efficacy and safety of strontium ranelate in knee osteoarthritis.2 Obesity and overweight are recognised risk factors for osteoarthritis,3 and so it is essential to include such patients in studies of potential treatments, since they are likely to constitute a substantial proportion of the patients who …

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