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Investigation of C reactive protein gene polymorphisms as predictors of cardiovascular mortality in inflammatory polyarthritis: results from the Norfolk Arthritis Register
  1. Ibrahim Ibrahim1,
  2. Darren Plant1,2,
  3. Mark Lunt1,
  4. Suzanne Verstappen1,
  5. Edward Flynn1,
  6. Deborah Symmons1,2,
  7. Anne Barton1,2
  1. 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
  2. 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
  1. Correspondence to Prof Anne Barton, Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK; anne.barton{at}

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Patients with rheumatoid arthritis (RA) and inflammatory polyarthritis (IP) are at increased risk of premature death, with cardiovascular disease (CVD) forming the primary cause.1–3 However, epidemiological studies have shown that traditional CVD risk factors do not fully account for the increased risk.4 ,5

We have previously reported that IP patients with baseline C reactive protein (CRP) concentrations ≥5 mg/l are at greatest risk of CVD mortality.6 Previous studies have shown that single nucleotide polymorphisms (SNPs) at the CRP gene correlate with CRP levels in a healthy population,7 and haplotypes of these SNPs are associated with CRP levels following acute coronary syndrome.8 Therefore, if CRP SNPs/haplotypes were associated with CVD in individuals with IP, it would implicate CRP in the pathogenesis of CVD (Mendelian randomisation).

The aims of this study were (1) to determine the relationship between SNP markers (rs1205, rs1800947 and rs3091244) in the CRP gene, selected …

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