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Establishing the diagnosis of giant cell arteritis (GCA) may be challenging. In the absence of validated biological marker1 and despite imaging technique contribution,2 the diagnosis of GCA currently relies on temporal artery biopsy (TAB). Autoantibodies have been identified in GCA3–6 and recently, Baerlecken et al7 detected IgG antibodies directed against a peptide of the human ferritin heavy chain (FTH1) in 92% of untreated GCA and polymyalgia rheumatica at first diagnosis versus 1% of healthy controls (HC).
In order to evaluate the diagnosis value of these antibodies, we tested sera from 122 consecutive patients suspected of GCA at the time of TAB. Based on the American College of Rheumatology (ACR) criteria,8 40 patients had biopsy-proven GCA (TAB+GCA), 29 patients had biopsy-negative GCA (TAB−GCA), 47 patients received another diagnosis than GCA (GCA controls) and 6 patients had polymyalgia rheumatica (collection dc-2010–1079). Sera from 40 healthy blood donors were used as HCs. All patients and controls gave signed informed consent. The study was approved by the ethics …