Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

Anne-Marie Quirke; Elena Birgitta Lugli; Natalia Wegner; Bart C Hamilton; Peter Charles; Muslima Chowdhury; A Jimmy Ytterberg; Roman A Zubarev; Jan Potempa; Shauna Culshaw; Yonghua Guo; Benjamin A Fisher; Geoffrey Thiele; Ted R Mikuls; Patrick JW Venables

doi:10.1136/annrheumdis-2012-202726

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Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis

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Mar 2013	631	213	278
Apr 2013	462	132	141
May 2013	138	107	96
Jun 2013	116	92	57
Jul 2013	109	71	59
Aug 2013	141	53	44
Sep 2013	62	87	63
Oct 2013	37	81	56
Nov 2013	35	102	43
Dec 2013	271	84	155
Jan 2014	89	74	135
Feb 2014	74	55	112
Mar 2014	80	61	44
Apr 2014	71	94	67
May 2014	61	105	52
Jun 2014	52	68	48
Jul 2014	54	38	16
Aug 2014	47	36	30
Sep 2014	30	48	47
Oct 2014	81	37	43
Nov 2014	39	36	36
Dec 2014	29	17	36
Jan 2015	29	61	30
Feb 2015	24	34	21
Mar 2015	37	29	22
Apr 2015	35	26	26
May 2015	34	28	17
Jun 2015	30	17	31
Jul 2015	50	24	23
Aug 2015	70	19	35
Sep 2015	45	28	27
Oct 2015	17	5	22
Nov 2015	27	14	29
Dec 2015	63	26	26
Jan 2016	50	20	21
Feb 2016	44	17	16
Mar 2016	18	12	32
Apr 2016	56	12	16
May 2016	39	25	28
Jun 2016	32	13	13
Jul 2016	28	11	38
Aug 2016	24	11	17
Sep 2016	20	19	13
Oct 2016	36	19	29
Nov 2016	47	18	19
Dec 2016	113	29	59
Jan 2017	27	20	14
Feb 2017	19	20	17
Mar 2017	7	27	36
Apr 2017	23	17	16
May 2017	25	20	14
Jun 2017	12	17	10
Jul 2017	18	13	2
Aug 2017	39	30	6
Sep 2017	42	38	16
Oct 2017	44	36	11
Nov 2017	46	30	8
Dec 2017	36	20	5
Jan 2018	36	22	24
Feb 2018	68	46	11
Mar 2018	50	40	13
Apr 2018	55	38	33
May 2018	81	59	23
Jun 2018	57	37	10
Jul 2018	41	13	8
Aug 2018	30	20	11
Sep 2018	40	26	9
Oct 2018	64	42	10
Nov 2018	44	30	16
Dec 2018	74	44	10
Jan 2019	53	32	18
Feb 2019	54	37	17
Mar 2019	53	43	22
Apr 2019	67	54	23
May 2019	30	22	13
Jun 2019	32	20	25
Jul 2019	30	17	18
Aug 2019	39	23	32
Sep 2019	48	34	26
Oct 2019	43	27	12
Nov 2019	46	38	20
Dec 2019	56	39	21
Jan 2020	46	22	27
Feb 2020	29	23	21
Mar 2020	38	30	21
Apr 2020	23	10	32
May 2020	24	15	9
Jun 2020	22	16	15
Jul 2020	34	23	18
Aug 2020	40	36	21
Sep 2020	35	33	22
Oct 2020	9	9	10
Nov 2020	22	20	16
Dec 2020	39	27	20
Jan 2021	29	25	25
Feb 2021	32	16	10
Mar 2021	36	24	16
Apr 2021	24	17	17
May 2021	22	21	9
Jun 2021	15	15	12
Jul 2021	19	19	23
Aug 2021	16	14	18
Sep 2021	44	44	21
Oct 2021	41	27	28
Nov 2021	31	23	42
Dec 2021	45	33	19
Jan 2022	38	32	14
Feb 2022	33	22	24
Mar 2022	56	47	17
Apr 2022	47	35	26
May 2022	40	35	32
Jun 2022	47	43	13
Jul 2022	30	22	12
Aug 2022	32	30	12
Sep 2022	52	38	71
Oct 2022	43	38	22
Nov 2022	33	31	14
Dec 2022	42	43	13
Jan 2023	66	59	21
Feb 2023	78	68	18
Mar 2023	75	53	20
Apr 2023	40	28	23
May 2023	29	21	17
Jun 2023	45	33	19
Jul 2023	29	23	15
Aug 2023	32	27	18
Sep 2023	38	36	10
Oct 2023	109	87	19
Nov 2023	176	145	12
Dec 2023	86	45	33
Jan 2024	50	43	29
Feb 2024	62	48	14
Mar 2024	45	30	12
Total	7374	5003	3870

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