Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

Stacy P Ardoin; Laura Eve Schanberg; Christy I Sandborg; Huiman X Barnhart; Greg W Evans; Eric Yow; Kelly L Mieszkalski; Norman T Ilowite; Anne Eberhard; Lisa F Imundo; Yuki Kimura; Deborah Levy; Emily von Scheven; Earl Silverman; Suzanne L Bowyer; L Punaro; Nora G Singer; David D Sherry; Deborah K McCurdy; Marissa Klein-Gitelman; Carol Wallace; Richard M Silver; Linda Wagner-Weiner; Gloria C Higgins; Hermine I Brunner; Lawrence Jung; Jennifer B Soep; Ann M Reed; Susan D Thompson; for the APPLE investigators

doi:10.1136/annrheumdis-2012-202315

Article info

Clinical and epidemiological research

Extended report

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

Authors

Stacy P Ardoin Department of Medicine, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Laura Eve Schanberg Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, North Carolina, USA PubMed articles Google scholar articles
Christy I Sandborg Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California, USA PubMed articles Google scholar articles
Huiman X Barnhart Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, North Carolina, USA PubMed articles Google scholar articles
Greg W Evans Departments of Biostatistical Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA PubMed articles Google scholar articles
Eric Yow Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, North Carolina, USA PubMed articles Google scholar articles
Kelly L Mieszkalski Department of Biostatistics and Bioinformatics, Duke Clinical Research Institute, Durham, North Carolina, USA PubMed articles Google scholar articles
Norman T Ilowite Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA PubMed articles Google scholar articles
Anne Eberhard Department of Pediatrics, Cohen Children's Medical Center, New Hyde Park, New York, USA PubMed articles Google scholar articles
Lisa F Imundo Department of Pediatrics, Columbia University Medical Center, New York, New York, USA PubMed articles Google scholar articles
Yuki Kimura Department of Pediatrics, Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center, Hackensack, New Jersey, USA PubMed articles Google scholar articles
Deborah Levy Department of Rheumatology, Toronto Hospital for Sick Children, Toronto, Ontario, Canada PubMed articles Google scholar articles
Emily von Scheven Department of Pediatrics, University of California at San Francisco, San Francisco, California, USA PubMed articles Google scholar articles
Earl Silverman Department of Rheumatology, Toronto Hospital for Sick Children, Toronto, Ontario, Canada PubMed articles Google scholar articles
Suzanne L Bowyer Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA (deceased) PubMed articles Google scholar articles
L Punaro Department of Rheumatology, Texas Scottish Rite Hospital for Children, Dallas, Texas, USA PubMed articles Google scholar articles
Nora G Singer Department of Medicine, University Hospitals/Case Medical Center, Cleveland, Ohio, USA PubMed articles Google scholar articles
David D Sherry Department of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Deborah K McCurdy Division of Pediatric Rheumatology, University of California Los Angeles School of Medicine, Los Angeles, California, USA PubMed articles Google scholar articles
Marissa Klein-Gitelman Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA PubMed articles Google scholar articles
Carol Wallace Department of Pediatric Rheumatology, Seattle Children's Hospital, Seattle, Washington, USA PubMed articles Google scholar articles
Richard M Silver Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articles Google scholar articles
Linda Wagner-Weiner Department of Pediatrics, University of Chicago, Chicago, Illinois, USA PubMed articles Google scholar articles
Gloria C Higgins Department of Medicine, Nationwide Children's Hospital, Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Hermine I Brunner Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Lawrence Jung Department of Rheumatology, Children's National Medical Center, Washington, DC, USA PubMed articles Google scholar articles
Jennifer B Soep Department of Rheumatology, The Children's Hospital, Denver, Colorado, USA PubMed articles Google scholar articles
Ann M Reed Department of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA PubMed articles Google scholar articles
Susan D Thompson Department of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA PubMed articles Google scholar articles
for the APPLE investigators
Google scholar articles

Correspondence to Dr Stacy P Ardoin, Departments of Pediatrics and Medicine, Ohio State University and Nationwide Children's Hospital, S2056 480 Medical Center Drive, Columbus, Ohio 43210, USA; stacy.ardoin{at}osumc.edu

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Citation

Ardoin SP, Schanberg LE, Sandborg CI, et al

Secondary analysis of APPLE study suggests atorvastatin may reduce atherosclerosis progression in pubertal lupus patients with higher C reactive protein

Annals of the Rheumatic Diseases 2014;73:557-566.

Publication history

Received July 6, 2012
Revised December 29, 2012
Accepted February 3, 2013
First published February 22, 2013.

Online issue publication

October 31, 2019

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