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We read with interest the article by Riddle et al1 entitled ‘Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis’, where the authors used data on a subset of 2207 subjects included in the Osteoarthritis Initiative with radiological suspected or confirmed knee osteoarthritis (OA). Their article was partly based on the article by Clockaerts et al,2 where we report an association between statin use, and incidence and progression of radiological knee OA in the Ommoord cohort of the Rotterdam study. Riddle et al also investigated the association between pain and function scores, progression of radiological knee OA and statin use, and found no associations.
Their data may indicate that there is indeed no association between statin use and knee OA, and that our results were due to an unexpected bias or …