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Comment on ‘Associations between statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis’
  1. Stefan Clockaerts1,2,3,
  2. G J V M Van Osch1,4,
  3. Sita M Bierma-Zeinstra1,5
  1. 1Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
  2. 2Monica Orthopedic Research (MoRe) Foundation and Monica Hospital, Antwerp, Belgium
  3. 3Department of Orthopaedic Surgery and Traumatology, University Hospital of Antwerp, Belgium
  4. 4Department of Otorhinolaryngology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
  5. 5Department of General Medicine, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
  1. Correspondence to Dr Stefan Clockaerts, Department of Orthopaedics, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands; s.clockaerts{at}erasmusmc.nl

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We read with interest the article by Riddle et al1 entitled ‘Associations between Statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis’, where the authors used data on a subset of 2207 subjects included in the Osteoarthritis Initiative with radiological suspected or confirmed knee osteoarthritis (OA). Their article was partly based on the article by Clockaerts et al,2 where we report an association between statin use, and incidence and progression of radiological knee OA in the Ommoord cohort of the Rotterdam study. Riddle et al also investigated the association between pain and function scores, progression of radiological knee OA and statin use, and found no associations.

Their data may indicate that there is indeed no association between statin use and knee OA, and that our results were due to an unexpected bias or …

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