Footnotes

• Handling editor Tore K Kvien

• Contributors TA, SS, BH, QC and SZ carried out most of the experiments; FH, RA, AT and AHR made substantial contributions to the conception and design of the study; TA, G-RB, RA and FH conducted the clinical trial; and TA, SS, AHR and FH wrote the manuscript. All authors read and approved the final manuscript.

• Funding This work was supported by the Deutsche Forschungsgemeinschaft (SFB650 TP12 and TP17).

• Competing interests None.

• Patient consent Obtained.

• Ethics approval Local IRB Berlin.

• Provenance and peer review Not commissioned; externally peer reviewed.