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Clinical and epidemiological research
Concise report
The genetic contribution to severe post-traumatic osteoarthritis
  1. Ana M Valdes1,2,
  2. Sally A Doherty1,
  3. Kenneth R Muir3,4,
  4. Margaret Wheeler1,
  5. Rose A Maciewicz5,
  6. Weiya Zhang1,
  7. Michael Doherty1
  1. 1Academic Rheumatology, Nottingham City Hospital, Nottingham, UK
  2. 2Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas’ Hospital, London, UK
  3. 3Health Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, UK
  4. 4Institute of Population Health, University of Manchester, Manchester, UK
  5. 5Respiratory & Inflammation Research Area, AstraZeneca, Charnwood R&D, Loughborough, Leicestershire, UK
  1. Correspondence to Dr Ana M Valdes, Department of Twin Research & Genetic Epidemiology, Kings College London, St Thomas Hospital campus, London SE1 7EH, UK; ana.valdes{at}kcl.ac.uk

Abstract

Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement.

Methods A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates.

Results For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063).

Conclusions Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.

  • Osteoarthritis
  • Gene Polymorphism
  • Epidemiology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/annrheumdis-2012-202562

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