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Recent studies have highlighted significant risks associated with metal-on-metal (MoM) hip joint replacement,1 leading Smith et al 2 to recommend that research should be ‘focused on understanding the biological consequences of exposure to orthopaedic metals’. One of these consequences may be the development of solid or fluid-filled inflammatory lesions, termed pseudotumours, which have been reported in areas around MoM joints.3 ,4
The articulating surface of MoM joints is fabricated from a hard alloy containing approximately one part chromium to two of cobalt. Ionic forms of both these metals can be detected at a high level (≤5 mM Cr, ≤0·25 mM Co) in the synovial fluid surrounding MoM joints, with lower levels present in distant body tissues, blood and urine.5 Although …
Footnotes
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Contributions All authors contributed to the concept of the study and study design. HL was involved in data collection and data analysis. AJT-C and JAK were involved in preparation of the figure, data analysis, data interpretation and writing the manuscript.
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Funding This work is supported by the Newcastle NIHR Biomedical Research Centre.
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Competing interests None.
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Provenance and peer review Not commissioned; externally peer reviewed.