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The development of arthritis and antinuclear antibodies correlate with serum 25-hydroxyvitamin D levels in patients with leprosy
  1. Sandra L E Ribeiro1,
  2. Helena L A Pereira1,
  3. Cristovao Luis Mangueira2,
  4. Carlos E S Ferreira2,
  5. Eliane Rosseto2,
  6. Morton Scheinberg2
  1. 1Department of Internal Medicine, Universidade Federal do Amazonas, Manaus, Brazil
  2. 2Department of Rheumatology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
  1. Correspondence to Professor Morton Scheinberg, Department of Rheumatology, Hospital Israelita Albert Einstein, Av Albert Einstein, Sao Paulo 05652 000, Brazil; morton{at}osite.com.br

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Leprosy, a chronic granulomatous infection, presents with cutaneous and neurological manifestations. Musculoskeletal involvement, though the third most common manifestation, is underdiagnosed.1 ,2 In its natural history, other immune manifestations besides articular manifestations may be present, such as the presence of autoantibodies.3 ,4 There is evidence that vitamin D influences the activity of immune-mediated diseases, particularly autoimmune diseases.5 ,6 Amazon is a state in the northern part of Brazil where the disease is endemic. It has a high level of sunshine, so a low prevalence of vitamin D insufficiency would be expected. In this study we looked at the serum vitamin D …

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