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Investigation of IL1, VEGF, PPARG and MEFV genes in psoriatic arthritis susceptibility
  1. John Bowes1,
  2. Pauline Ho1,2,
  3. Edward Flynn1,
  4. Salma Salah1,
  5. Neil McHugh3,
  6. Oliver FitzGerald4,
  7. Jonathan Packham5,
  8. Ann W Morgan6,
  9. Philip S Helliwell7,
  10. Ian N Bruce1,2,
  11. Anne Barton1,2
  1. 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK
  2. 2The Kellgren Centre for Rheumatology, Central Manchester Foundation Trust, NIHR Manchester Biomedical Research Centre, Manchester, UK
  3. 3Royal National Hospital for Rheumatic Diseases and Department Pharmacy and Pharmacology, University of Bath, Bath, UK
  4. 4Department of Rheumatology, St Vincent's University Hospital, UCD School of Medicine and Medical Sciences and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
  5. 5Stoke on Trent Arthritis Research UK Primary Care Centre, Haywood Hospital, Keele University, Keele, UK
  6. 6NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
  7. 7Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK
  1. Correspondence toProfessor Anne Barton, Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, Stopford Building, University of Manchester, Manchester, UK; anne.barton{at}manchester.ac.uk

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Psoriatic arthritis (PsA) is characterised by joint inflammation in patients with psoriasis or a family history of psoriasis. A study of the Icelandic genealogical database supports a strong genetic component with a 40-fold increased risk of disease in first-degree relatives of patients with PsA.1 In order to identify genes that predispose to disease, two study designs have become prominent in recent years: the candidate gene and the genome-wide association (GWA) approach, using case-control cohorts.

Although GWA studies allow a comprehensive analysis of the genome for susceptibility variants, they remain expensive and only three GWAs in PsA have been published to date.2,,4 These have identified the HLA C, IL23R, IL12B, IL13 and TRAF3IP2 genes as being robustly associated with PsA. Due to issues of multiple testing, only those loci that reach stringent significance thresholds can claim to show confirmed association with PsA. …

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