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Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis
  1. Ladislav Šenolt1,
  2. Markéta Kuklová1,
  3. Lucie Andrés Cerezo1,
  4. Hana Hulejová1,
  5. Maria Filková1,
  6. Lenka Bošanská2,
  7. Ondřej Pecha3,
  8. Karel Pavelka1,
  9. Martin Haluzík2,
  10. Jiří Vencovský1
  1. 1Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
  2. 23rd Medical Department—Clinical Department of Endocrinology and Metabolism of the 1st Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic
  3. 3Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
  1. Correspondence to Ladislav Šenolt, Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, 1st Faculty of Medicine, Charles University, Na Slupi 4, 12850 Prague 2, Czech Republic; seno{at}revma.cz

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A protective effect of obesity showing that increased adiposity protects against radiographic joint damage in patients with rheumatoid arthritis (RA) has been reported.1 2 Recently, adipokines were suggested as a molecular link explaining this paradoxical association.3,,5 The levels of serum adiponectin and visfatin have been shown to be associated with increased, radiographic joint damage in RA, while leptin is associated with reduced radiographic joint damage.4 5 Therefore, we tested whether tumour necrosis factor α (TNFα) inhibitor therapy, which prevents joint damage in majority of patients with RA, may be associated with a change in the local production of adipokines in subcutaneous adipose tissue (SAT).

SAT samples were obtained from the same abdominal region by aspiration with a bioptic needle in nine patients with RA prior to and 6 months after the treatment with etanercept. Adipose tissue samples were …

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