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Surrogate markers of B cell non-Hodgkin's lymphoma in patients with hepatitis C virus-related cryoglobulinaemia vasculitis
  1. Guillaume Geri1,2,
  2. Benjamin Terrier1,2,
  3. Oren Semoun3,
  4. David Saadoun1,2,
  5. Damien Sène1,2,
  6. Frédéric Charlotte4,
  7. Hélène Merle-Béral5,
  8. Lucile Musset6,
  9. Matthieu Resche-Rigon3,
  10. Patrice Cacoub1,2
  1. 1Service de Médecine Interne II, Hôpital Pitié Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
  2. 2CNRS UMR 7211 Université Pierre et Marie Curie, Paris, France
  3. 3Département d’Informatique Médicale et de Biostatistiques, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France
  4. 4Service d’Anatomo-Pathologie, Hôpital Pitié Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
  5. 5Service d’Hématologie Biologique, Hôpital Pitié Salpetriere, Assistance Publique-Hôpitaux de Paris, Paris, France
  6. 6Service d’immunochimie, Hôpital Pitié-Salpétrière, Assistance Publique-Hôpitaux de Paris, Paris, France
  1. Correspondence to Patrice Cacoub, Service de Médecine Interne Hôpital La Pitié-Salpêtrière, 47–83 Boulevard de l’Hôpital, 75651 Cedex 13, Paris, France; patrice.cacoub{at}psl.aphp.fr

Abstract

Objective To evaluate clinical and biological surrogate markers associated with the presence of B cell non-Hodgkin's lymphoma (B-NHL) in patients with hepatitis C virus (HCV) with mixed cryoglobulinaemia (MC) vasculitis.

Methods A total of 104 patients with HCV-MC vasculitis (including 20 with B-NHL) were included. The main clinical and biological markers associated with the presence of B-NHL were evaluated.

Results Patients with B-NHL compared to those without showed higher rates of poor general status (40% vs 16.7%; p=0.032), purpura (90% vs 66.7%; p=0.05), renal (50% vs 28.6%; p=0.11) and cardiac involvement (15% vs 0%; p=0.0006), higher cryoglobulin levels (1.44 g/litre vs 0.67 g/litre; p=0.0004), and lower C4 (0.025 g/litre vs 0.06 g/litre; p=0.001) and γ-globulin levels (5.3 g/litre vs 13.3 g/litre; p<0.0001). The free light chain κ/λ ratio was more frequently abnormal in patients with than without B-NHL (64.3% vs 33.3%, p=0.10). On multivariate analysis, only γ-globulin level was associated with the presence of B-NHL (OR 0.77 (95% CI −0.44 to −0.13), p=0.0006). The optimal cut-off value for γ-globulin level was 9 g/litre, with sensitivity, specificity, positive and negative predictive values for the presence of B-NHL of 75%, 82%, 50% and 93%, respectively.

Conclusions In patients with HCV-MC, a low γ-globulin level (<9 g/litre) is strongly associated with the presence of B-NHL.

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Footnotes

  • GG and BT contributed equally to this work.

  • Ethics approval This study was conducted with the approval of the Hôpital Pitié Salpetriere.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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