Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D?
- H Amital1,
- Z Szekanecz2,
- G Szücs2,
- K Dankó3,
- E Nagy4,
- T Csépány5,
- E Kiss6,
- J Rovensky7,
- A Tuchynova7,
- D Kozakova7,
- A Doria8,
- N Corocher9,
- N Agmon-Levin10,
- V Barak11,
- H Orbach12,
- G Zandman-Goddard13,
- Y Shoenfeld10
- 1Department of Internal Medicine, ‘D’ Meir Medical Centre, Kfar-Saba, Israel
- 2Department of Rheumatology, University of Debrecen Medical and Health Sciences Centre, Debrecen, Hungary
- 3Division of Clinical Immunology, Third Department of Medicine, University of Debrecen Medical and Health Sciences Centre, Debrecen, Hungary
- 4Division of Endocrinology, First Department of Medicine, University of Debrecen Medical and Health Sciences Centre, Debrecen, Hungary
- 5Department of Neurology, University of Debrecen Medical and Health Sciences Centre, Debrecen, Hungary
- 6National Institute of Rheumatology and Physiotherapy, Budapest, Hungary
- 7National Institute of Rheumatic Diseases, Piest'any, Slovak Republic
- 8Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy
- 9DiaSorin S.p.A, Strada per Crescentino snc, Vercelli, Italy
- 10Department of Internal Medicine B and The Centre for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel
- 11Immunology Laboratory for Tumor Diagnosis, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel
- 12Department of Medicine ‘B’, Wolfson Medical Centre, Holon, Israel and Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel
- 13Department of Medicine ‘C’, Wolfson Medical Centre, Holon, Israel and Sackler Faculty of Medicine Tel Aviv University, Tel Aviv, Israel
- Correspondence to Professor Yehuda Shoenfeld, Department of Medicine ‘B’ and Centre for Autoimmune Diseases, Sheba Medical Centre, (Affiliated to Tel-Aviv University) Tel-Hashomer 52621, Israel;
- Accepted 8 November 2009
- Published Online First 3 May 2010
Background Low serum vitamin D concentrations have been reported in several autoimmune disorders.
Objective To assess whether low serum vitamin D concentrations are related to disease activity of patients with systemic lupus erythematosus (SLE).
Methods 378 patients from several European and Israeli cohorts were pooled and their disease activity was measured by two different methods: 278 patients had SLE disease activity-2000 (SLEDAI-2K) scores and 100 patients had European Consensus Lupus Activity Measurement (ECLAM) scores. In order to combine the two systems the scores were converted into standardised values (z-scores), enabling univariate summary statistics for the two variables (SLEDAI-2K and ECLAM). The commercial kit, LIAISON 25-OH vitamin D assay (310900-Diasorin) was used to measure serum concentration of 25-OH vitamin D in 378 patients with SLE.
Results A significant negative correlation was demonstrated between the serum concentration of vitamin D and the standardised values (z-scores) of disease activity scores as measured by the SLEDAI-2K and ECLAM scales (Pearson's correlation coefficient r=−0.12, p=0.018).
Conclusions In a cohort of patients with SLE originating from Israel and Europe vitamin D serum concentrations were found to be inversely related to disease activity.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.