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Organ-specific autoantibodies but not anti-cyclic citrullinated peptides are a feature of autoimmunity in Down's syndrome
  1. Benjamin A Fisher1,
  2. Peter Charles1,
  3. Karin Lundberg1,
  4. Kathleen M Gillespie2,
  5. Richard W Newton3,
  6. Patrick J Venables1
  1. 1Kennedy Institute of Rheumatology, Imperial College, London, UK
  2. 2Diabetes and Metabolism Unit, University of Bristol, UK
  3. 3Department of Paediatric Neurology, Royal Manchester Children's Hospital, UK
  1. Correspondence to Dr Benjamin Fisher, Department of Rheumatology, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK; Benjamin.fisher{at}imperial.ac.uk

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There is a well-recognised association of Down's syndrome with certain autoimmune diseases, in particular, thyroid autoimmunity, type 1 diabetes and coeliac disease. Recent publications have also reported an unexpectedly high prevalence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) antibodies.1 2 The recent identification of a potential susceptibility locus for rheumatoid arthritis (RA) at 21q22 in a genome-wide study3 further suggests the possibility of RA also being associated with trisomy 21.

Sera from 104 subjects with Down's syndrome, mean age 14.4 years (range 10–20), the Hester Adrian Research Centre population-based cohort, were obtained with informed consent and ethical …

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