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No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort
  1. Stephen Eyre1,
  2. Edward Flynn1,
  3. Paul Martin1,
  4. Anne Hinks1,
  5. Anthony G Wilson2,
  6. Ann W Morgan3,
  7. Paul Emery3,
  8. Sophia Steer4,
  9. Lynne J Hocking5,
  10. David M Reid5,
  11. Pille Harrison6,
  12. Paul Wordsworth6,
  13. Wendy Thomson1,
  14. Jane Worthington1,
  15. Anne Barton1
  1. 1arc-Epidemiology Unit, Stopford Building, Manchester Academy of Health Sciences, The University of Manchester, Manchester, UK
  2. 2School of Medicine and Biomedical Sciences, Sheffield University, Sheffield, UK
  3. 3NIHR-Leeds Musculoskeletal Biomedical Research Unit, Leeds Institute of Molecular Medicine, University of Leeds, UK
  4. 4Clinical and Academic Rheumatology, King's College Hospital NHS Foundation Trust, London, UK
  5. 5Musculoskeletal and Genetics Section, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK
  6. 6University of Oxford Institute of Musculoskeletal Sciences, Botnar Research Centre, Oxford, UK
  1. Correspondence to Dr Anne Barton, arc
    -Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK; anne.barton{at}manchester.ac.uk

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Genome-wide association studies (GWAS) have heralded a major breakthrough in the search for genes underlying rheumatoid arthritis (RA). Indeed, GWAS in UK, US and Swedish populations have identified a number of confirmed RA loci.1 Recently, a modestly-sized GWAS was undertaken in a Spanish population comprising 400 patients with RA and 400 controls.2 Association with the KLF12 gene was detected (p=6.5×10−6) and subsequently replicated in an independent cohort of 410 Spanish patients with RA and 394 controls (p=0.01). The most strongly associated single nucleotide polymorphism (SNP) was rs1324913 mapping to intron 1 of the KLF12 gene. The KLF12 protein is a repressor for a transcriptional regulatory factor, AP-2α, which has been implicated in the control of inflammation. Other SNPs at this locus also showed weak evidence for association with RA in …

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