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Clinical and epidemiological research
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ARTS1 polymorphisms are associated with ankylosing spondylitis in Koreans
  1. Chan-Bum Choi1,
  2. Tae-Hwan Kim1,
  3. Jae-Bum Jun1,
  4. Hye-Soon Lee1,
  5. Seung Cheol Shim2,
  6. Bitnara Lee1,
  7. Angela Pope3,
  8. Mohammed Uddin4,
  9. Proton Rahman4,
  10. Robert D Inman5
  1. 1The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Republic of Korea
  2. 2Eulji School of Medicine, Daejeon, South Korea
  3. 3Newfound Genomics, Newfoundland, Canada
  4. 4Memorial University of Newfoundland, Newfoundland, Canada
  5. 5Toronto Western Hospital, University of Toronto, Toronto, Canada
  1. Correspondence to Professor Tae-Hwan Kim, The Hospital for Rheumatic Diseases, Hanyang University, Seoul 133-792, Republic of Korea; thkim{at}hanyang.ac.kr

Abstract

Objective To test the association between ARTS1 polymorphisms and Koreans with ankylosing spondylitis (AS).

Methods All patients and controls were Korean. 872 patients with AS fulfilling the modified New York criteria and 403 healthy controls were genotyped for five single nucleotide polymorphisms (SNPs), rs27044, rs17482078, rs10050860, rs30107 and rs2287987, known to be associated with AS in Caucasians.

Results SNPs rs27044 (p=9.37 × 10−7) and rs30187 (p=7.16 × 10−6) of ARTS1 were significantly associated with AS in Koreans. There was no significant association for rs17482078, rs10050860 and rs2287987. Two four-marker haplotypes were found to be associated with AS (GCCT: p=4.71×10−7, CCCC: p=8.56×10−6).

Conclusions This is first confirmation in a non-Caucasian population that genetic polymorphisms in ARTS1 are associated with AS, implicating common pathogenetic mechanisms in Korean and Caucasian patients with AS.

https://doi.org/10.1136/ard.2008.105296

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    Footnotes

    • Competing interests None.

    • Ethics approval This study was conducted with the approval of the Hanyang University Medical Centre.

    • Provenance and peer review Not commissioned; externally peer reviewed.