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Increased accumulation of advanced glycation endproducts in patients with Wegener’s granulomatosis
  1. Karina de Leeuw*,
  2. Hans L A Nienhuis,
  3. Andries J Smit,
  4. Coen A Stegeman,
  5. Cees G M Kallenberg,
  6. Marc Bijl
  1. University Medical Center Groningen, Netherlands
  1. Correspondence to: Karina de Leeuw, Internal Medicine, University Medical Center Groningen, PO Box 30.001, Groningen, 9700 RB, Netherlands; k.de.leeuw{at}int.umcg.nl

Abstract

Wegener’s granulomatosis (WG) is a systemic autoimmune disease characterized by an increased risk for cardiovascular disease due to accelerated atherosclerosis, which cannot be fully explained by traditional risk factors.1 Therefore, non-traditional risk factors are probably involved. Among these, accumulation of advanced glycation endproducts (AGEs) might be important. AGEs are implicated in vascular pathology2 and are independent predictors of cardiovascular mortality in diabetic and hemodialysis patients.3;4

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