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TREX1 Gene Variant in Neuropsychiatric Systemic Lupus Erythematosus
  1. Boukje de Vries,
  2. Gerda Steup-Beekman,
  3. Joost Haan,
  4. Edward Bollen,
  5. Jasper Luyendijk,
  6. Rune Frants,
  7. Gisela Terwindt,
  8. Mark van Buchem,
  9. Tom Huizinga,
  10. Arn van den Maagdenberg,
  11. Michel Ferrari*
  1. Leiden University Medical Center, Netherlands
  1. Correspondence to: Michel D Ferrari, LUMC, PO Box, Leiden, 0, Netherlands;{at}


Systemic lupus erythematosus (SLE) is an autoimmune disorder with a complex genetic background. Some 14-75% of SLE patients report neurological and psychiatric symptoms and are diagnosed with neuropsychiatric-SLE (NPSLE).1 Many of these patients also have cerebral white matter hyperintensities (WMH). The etiology and genetic background of NPSLE is largely unknown.

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