Article Text

other Versions

PDF
SLC22A12 Gene is Associated with Gout in Han Chinese and Solomon Islanders
  1. Hung-Pin Tu (p915013{at}kmu.edu.tw)
  1. Department of Public Health and Environmental Medicine, Faculty of Medicine, College of Medicine, Ka, Taiwan
    1. Chung-Jen Chen (chungjen{at}adm.cgmh.org.tw)
    1. Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memor, Taiwan
      1. Chien-Hung Lee (cnhung{at}kmu.edu.tw)
      1. Department of Public Health, Kaohsiung Medical University, Taiwan
        1. Silent Tovosia (stovosia{at}adventist.org.sb)
        1. National Referral Hospital, Ministry of Health and Medical Services, Solomon Islands
          1. Albert Min-Shan Ko (4lbertko{at}gmail.com)
          1. Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Taiwan
            1. Shu-Jung Wang (wangsj{at}cc.kmu.edu.tw)
            1. Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Taiwan
              1. Tsan-Teng Ou (tsanteng{at}yahoo.com.tw)
              1. Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan
                1. Gau-Tyan Lin (gtlin{at}kmu.edu.tw)
                1. Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Taiwan
                  1. Shang-Lun Chiang (r890088{at}kmu.edu.tw)
                  1. Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Taiwan
                    1. Hung-Che Chiang (hcchiang{at}kmu.edu.tw)
                    1. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan
                      1. Ping-Ho Chen (phchen{at}nhri.org.tw)
                      1. Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taiwan
                        1. Shun-Jen Chang (changsj{at}kmu.edu.tw)
                        1. Department of Public Health and Environmental Medicine, Faculty of Medicine, College of Medicine, Ka, Taiwan
                          1. Han-Ming Lai (laihm{at}ms31.hinet.net)
                          1. Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memor, Taiwan
                            1. Ying-Chin Ko (ycko{at}kmu.edu.tw)
                            1. Department of Public Health and Environmental Medicine, Faculty of Medicine, College of Medicine, Ka, Taiwan

                              Abstract

                              Gout is characterised by monosodium urate crystals in hyperuricemic individuals.[1, 2] Impaired excretion of urate exacerbates this condition.[1] Urate transporter 1 (encoded by SLC22A12) is an urate-anion exchanger in the kidneys mediating urate transportation across the proximal tubules' apical membrane.[3, 4] SLC22A12 has been reported to influence urate homeostasis in Caucasian and Japanese[5-8] but SNPs' genotype effect on gout is unclear. We studied four SLC22A12 single-nucleotide polymorphisms' (SNPs) associations with gout and urate levels in male Han Chinese of Taiwan and Solomon Islanders.

                              Statistics from Altmetric.com

                              Request permissions

                              If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.