Gout is characterised by monosodium urate crystals in hyperuricemic individuals.[1, 2] Impaired excretion of urate exacerbates this condition. Urate transporter 1 (encoded by SLC22A12) is an urate-anion exchanger in the kidneys mediating urate transportation across the proximal tubules' apical membrane.[3, 4] SLC22A12 has been reported to influence urate homeostasis in Caucasian and Japanese[5-8] but SNPs' genotype effect on gout is unclear. We studied four SLC22A12 single-nucleotide polymorphisms' (SNPs) associations with gout and urate levels in male Han Chinese of Taiwan and Solomon Islanders.
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