Article Text

other Versions

PDF
Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population.
  1. Ikue Ito (s0921344{at}u.tsukuba.ac.jp)
  1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
    1. Aya Kawasaki (a-kawasaki{at}umin.net)
    1. University of Tsukuba, Fraduate School of Comprehensive Human Sciences, Japan
      1. Satoshi Ito (s-ito{at}md.tsukuba.ac.jp)
      1. University of Tsukuba, Fraduate School of Comprehensive Human Sciences, Japan
        1. Yuya Kondo (u_ya_kond{at}yahoo.co.jp)
        1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
          1. Masato Sugihara (sugihara{at}med.email.ne.jp)
          1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
            1. Masanobu Horikoshi (takkyyz{at}hotmail.com)
            1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
              1. Taichi Hayashi (t.hayashi{at}md.tsukuba.ac.jp)
              1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
                1. Daisuke Goto (dgoto{at}md.tsukuba.ac.jp)
                1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
                  1. Isao Matsumoto (ismatsu{at}md.tsukuba.ac.jp)
                  1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
                    1. Akito Tsutsumi (tsutsumi{at}med.takikawa.hokkaido.jp)
                    1. Takikawa Municipal Hospital, Japan
                      1. Yoshinari Takasaki (tyoshi{at}med.juntendo.ac.jp)
                      1. Juntendo University, Division of Rheumatology, Japan
                        1. Hiroshi Hashimoto (hhashi{at}mountain.ocn.ne.jp)
                        1. Juntendo University School of Medicine, Japan
                          1. Kunio Matsuta (kunio1944{at}jcom.home.ne.jp)
                          1. Matsuta Clinic, Japan
                            1. Takayuki Sumida (tsumida{at}md.tsukuba.ac.jp)
                            1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan
                              1. Naoyuki Tsuchiya (tsuchiya-tky{at}umin.ac.jp)
                              1. University of Tsukuba, Graduate School of Comprehensive Human Sciences, Japan

                                Abstract

                                Polymorphisms in the genomic region encoding B lymphoid tyrosine kinase (BLK) and family with sequence similarity 167, member A (FAM167A, also referred to as C8orf13) at 8p23.1 have been associated with systemic lupus erythematosus (SLE) in Caucasian[1,2] and Asian[3,4] populations. A recent genome-wide study in a north-American population demonstrated new associations with rheumatoid arthritis (RA), among which was a single nucleotide polymorphism (SNP) rs2736340 in the intergenic region of BLK and FAM167A.[5] In the HapMap Japanese samples (http://www.hapmap.org/index.html.ja), this SNP is in absolute linkage disequilibrium (r2=1) with rs13277113, previously associated with SLE.[1-4] We demonstrated that both the population frequency of the risk genotype, rs13277113A/A, and the odds ratio (OR) for SLE were substantially higher in the Japanese compared with the Caucasian populations.[3]

                                Statistics from Altmetric.com

                                Request permissions

                                If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.