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Associations of a nonsynonymous variant in SLC2A9 with gouty arthritis and uric acid levels in Han Chinese and Solomon Islanders
  1. Hung-Pin Tu (p915013{at}kmu.edu.tw)
  1. Kaohsiung Medical University, Taiwan
    1. Chung-Jen Chen (chungjen{at}adm.cgmh.org.tw)
    1. Chang Gung University College of Medicine, Taiwan
      1. Silent Tovosia (stovosia{at}adventist.org.sb)
      1. National Referral Hospital, Ministry of Health and Medical Services, Solomon Islands
        1. Albert Min-Shan Ko (4lbertko{at}gmail.com)
        1. Kaohsiung Medical University, Taiwan
          1. Chien-Hung Lee (cnhung{at}kmu.edu.tw)
          1. Kaohsiung Medical University, Taiwan
            1. Tsan-Teng Ou (tsanteng{at}yahoo.com.tw)
            1. Kaohsiung Medical University, Taiwan
              1. Gau-Tyan Lin (gtlin{at}kmu.edu.tw)
              1. Kaohsiung Medical University, Taiwan
                1. Shun-Jen Chang (changsj{at}kmu.edu.tw)
                1. Kaohsiung Medical University, Taiwan
                  1. Shang-Lun Chiang (r890088{at}kmu.edu.tw)
                  1. Kaohsiung Medical University, Taiwan
                    1. Hung-Che Chiang (hcchiang{at}kmu.edu.tw)
                    1. Kaohsiung Medical University, Taiwan
                      1. Ping-Ho Chen (phchen{at}nhri.org.tw)
                      1. Kaohsiung Medical University, Taiwan
                        1. Shu-Jung Wang (wangsj{at}cc.kmu.edu.tw)
                        1. Kaohsiung Medical University, Taiwan
                          1. Han-Ming Lai (laihm{at}ms31.hinet.net)
                          1. Chang Gung University College of Medicine, Taiwan
                            1. Ying-Chin Ko (ycko{at}kmu.edu.tw)
                            1. Kaohsiung Medical University and National Health Research Institutes, Taiwan

                              Abstract

                              Objective: To study the associations of gout, tophi, and uric acid levels with the gout-related SLC2A9 (solute carrier family 2, member 9) single-nucleotide polymorphisms (SNPs) between two different racial groups.

                              Methods: We genotyped eight SLC2A9 SNPs in 109 gout and 191 control subjects from male Han Chinese in Taiwan, and 69 gout and 168 control subjects from Solomon Islands.

                              Results: Nonsynonymous SLC2A9 rs3733591 Arg265His was associated with risk for gout and tophaceous gout in Han Chinese (p=0.0012 and p=0.0044). Genetic effect of this SNP on tophaceous gout was replicated in Solomon Islanders (p=0.0184). Patients with SLC2A9 Arg265His risk C-allele consistently had higher risk for tophi (OR=2.05-2.15) than non-tophi (OR=0.91-1.62). SNP rs3733591 described 3.68% and 5.98% of the total variability in uric acid levels for Chinese and Solomon Islands peoples, respectively.

                              Conclusion: Nonsynonymous SNP rs3733591 variant within SLC2A9 gene from two geographically diverse populations served as an important genetic checkpoint for tophaceous gout and increased uric acid levels.

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