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The diagnostic value of anti-MCV antibodies in differentiating early inflammatory arthritis
  1. L Damjanovska (ljubinkadr{at}yahoo.com)
  1. Rheumatology Clinic Dr. Dimitar Arsov, University Sts Cyril and Methodius, Skopje FYR, Macedonia
    1. M M Thabet (m.thabet{at}lumc.nl)
    1. Leiden University Medical Center, Netherlands
      1. E W N Levarht (e.w.n.levarht{at}lumc.nl)
      1. Leiden University Medical Center, Netherlands
        1. G Stoeken-Rijsbergen (g.stoeken-rijsbergen{at}lumc.nl)
        1. Leiden University Medical Center, Netherlands
          1. E I H van der Voort (e.i.h.van_der_voort{at}lumc.nl)
          1. Leiden University Medical Center, Netherlands
            1. R E M Toes (r.e.m.toes{at}lumc.nl)
            1. Leiden University Medical Center, Netherlands
              1. T W J Huizinga (t.w.j.huizinga{at}lumc.nl)
              1. Leiden University Medical Center, Netherlands
                1. A H M van der Helm-van Mil (a.h.m.van_der_helm{at}lumc.nl)
                1. Leiden University Medical Center, Netherlands

                  Abstract

                  Objectives: This study evaluates the diagnostic performance of the anti-CCP2, anti-CCP3 and anti-MCV tests in differentiating rheumatoid arthritis (RA) from other forms of arthritis in a clinical setting of early arthritis.

                  Methods: In 917 patients with recent-onset arthritis (566 RA, 351 other diseases) and in 99 healthy-controls the anti-MCV, anti-CCP2 and anti-CCP3.1 tests were performed and the test-characteristics compared.

                  Results: Comparing RA with other causes of arthritis revealed a lower specificity for anti-MCV (82.9%) than for anti-CCP2 (93.4%) and anti-CCP3.1 (90%). Similarly, the positive likelihood-ratio for anti-MCV was lower as well (3.6, compared to 8.7, 5,8 for anti-CCP2 and anti-CCP3.1). The anti-MCV test had a higher sensitivity (62% versus 56.9% and 58.1% respectively). In psoriatic-arthritis, ankylosing-spondylitis and other arthritis anti-MCV-antibodies had a prevalence of 15.2%, 13.9% and 19.4%.

                  Conclusion: The diagnostic performance of the anti-MCV test in the differential diagnosis of early arthritis is lower compared to the anti-CCP tests.

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