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ARTS1 polymorphisms are associated with ankylosing pondylitis in Koreans
  1. Chan-Bum Choi (cbchoi{at}hanyang.ac.kr)
  1. The Hospital for Rheumatic Diseases, Hanyang University, Korea, Republic of
    1. Tae-Hwan Kim (thkim{at}hanyang.ac.kr)
    1. The Hospital for Rheumatic Diseases, Hanyang University, Korea, Republic of
      1. Jae-Bum Jun
      1. The Hospital for Rheumatic Diseases, Hanyang University, Korea, Republic of
        1. Hye-Soon Lee
        1. The Hospital for Rheumatic Diseases, Hanyang University, Korea, Republic of
          1. Seung Cheol Shim
          1. Eulji School of Medicine, Korea, Republic of
            1. Bitnara Lee
            1. The Hospital for Rheumatic Diseases, Hanyang University, Korea, Republic of
              1. Angela Pope
              1. Newfound Genomics, Canada
                1. Mohammed Uddin
                1. Memorial University of Newfoundland, Canada
                  1. Proton Rahman
                  1. Memorial University of Newfoundland, Canada
                    1. Robert D Inman
                    1. Western Hospital, University of Toronto, Canada

                      Abstract

                      Objective: We tested the association between ARTs1 and Koreans with AS.

                      Methods: All patients and controls were Koreans. 872 AS patients fulfilling the modified New York criteria and 403 healthy controls were genotyped for five single nucleotide polymorphisms (SNPs), rs27044, rs17482078, rs10050860, rs30187, and, rs2287987, known to be associated with AS in Caucasians.

                      Results: SNPs rs27044 (p = 9.37 X 10-7) and rs30187 (p = 7.16 X 10-6) of ARTS1 were significantly associated with AS in Koreans. There was no significant association for rs17482078, rs10050860, and rs2287987. Two four marker haplotypes were found to be associated with AS (GCCT: p = 4.71 X 10-7, CCCC: p = 8.56 X 10-6).

                      Conclusions: This is first confirmation in a non-Caucasian population that genetic polymorphisms in ARTS1 are associated with AS, implicating common pathogenetic mechanisms in Korean and Caucasian AS.

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