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Ann Rheum Dis doi:10.1136/ard.2009.110593

Ankylosing spondylitis; a risk factor for myocardial infarction?

  1. M J L Peters (mjl.peters{at}vumc.nl)
  1. VU University Medical Center, Netherlands
    1. I Visman
    1. Jan van Breemen Institute, Netherlands
      1. M M J Nielen
      1. NIVEL, Netherlands
        1. N van Dillen
        1. Jan van Breemen Institute, Netherlands
          1. R A Verheij
          1. NIVEL, Netherlands
            1. I E van der Horst-Bruinsma
            1. VU University Medical Center, Netherlands
              1. B A C Dijkmans
              1. VU University Medical Center, Netherlands
                1. M T Nurmohamed (m.nurmohamed{at}janvanbreemen.nl)
                1. Jan van Breemen Institute, Netherlands
                  • Published Online First 28 April 2009

                  Abstract

                  Objectives: To ascertain the prevalence of myocardial infarction (MI) in ankylosing spondylitis (AS) relative to that in the general population.

                  Methods: A questionnaire was sent to 593 AS patients, aged between 50 and 75 years and registered at the Jan van Breemen Institute or VU University Medical Centre. A total of 383 (65%) AS patients returned their questionnaire that covered the primary outcome (non-fatal) MI. The prevalence for MI was calculated with data from the general population provided by Netherlands Information Network of General Practice databases as reference.

                  Results: The overall prevalence for MI was 4.4% in AS patients versus 1.2% in the general population, resulting in an age and gender adjusted odds ratio of 3.1 (95%CI: 1.9-5.1) for AS patients. When non-responders (35%) were considered as non-MI the odds ratio decreased to 1.9 (95%CI: 1.2-3.2).

                  Conclusions: Our observations indicate that the MI prevalence is increased in AS patients.