Ankylosing spondylitis; a risk factor for myocardial infarction?
- M J L Peters ( )
- M T Nurmohamed ( )
- Published Online First 28 April 2009
Objectives: To ascertain the prevalence of myocardial infarction (MI) in ankylosing spondylitis (AS) relative to that in the general population.
Methods: A questionnaire was sent to 593 AS patients, aged between 50 and 75 years and registered at the Jan van Breemen Institute or VU University Medical Centre. A total of 383 (65%) AS patients returned their questionnaire that covered the primary outcome (non-fatal) MI. The prevalence for MI was calculated with data from the general population provided by Netherlands Information Network of General Practice databases as reference.
Results: The overall prevalence for MI was 4.4% in AS patients versus 1.2% in the general population, resulting in an age and gender adjusted odds ratio of 3.1 (95%CI: 1.9-5.1) for AS patients. When non-responders (35%) were considered as non-MI the odds ratio decreased to 1.9 (95%CI: 1.2-3.2).
Conclusions: Our observations indicate that the MI prevalence is increased in AS patients.