Objective: To analyze the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.
Methods: We assigned mtDNA haplogroups to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and knee and/or hip OA patients (n = 977) were also analyzed in a multivariate analysis, after adjusting for sex, age and smoking.
Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR = 0.661; 95% CI: 0.440 – 0.993; p = 0.045). In addition to haplogroup J, smoking protects from the development of hip OA (OR = 0.543; 95% CI: 0.311 – 0.946; p = 0.031). However, no relationship was found between RA and mtDNA haplogroups.
Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups play a role in the complex osteoarthritic process.