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The role of European mtDNA haplogroups in the prevalence of hip osteoarthritis in Galicia (Northern Spain)
  1. Ignacio Rego (iregper{at}canalejo.org)
  1. INIBIC-Hospital Unversitario A Coruña, Spain
    1. Mercedes Fernández-Moreno (mfermor{at}canalejo.org)
    1. INIBIC-Hospital Unversitario A Coruña, Spain
      1. Carlos Fernández-López (cferlop{at}canalejo.org)
      1. INIBIC-Hospital Unversitario A Coruña, Spain
        1. Juan Gómez-Reino (juan.jose.gomez.reino.carnota{at}sergas.es)
        1. Hospital Clinico Universitario de Santiago, Spain
          1. Antonio González (antonio.gonzalez.martinez.pedrayo{at}sergas.es)
          1. Hospital Clinico Universitario de Santiago, Spain
            1. Joaquín Arenas (jarenas{at}isciii.es)
            1. Hospital 12 de Octubre, Spain
              1. Francisco J Blanco (francisco_blanco{at}canalejo.org)
              1. INIBIC-Hospital Unversitario A Coruña, Spain

                Abstract

                Objective: To analyze the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.

                Methods: We assigned mtDNA haplogroups to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and knee and/or hip OA patients (n = 977) were also analyzed in a multivariate analysis, after adjusting for sex, age and smoking.

                Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR = 0.661; 95% CI: 0.440 – 0.993; p = 0.045). In addition to haplogroup J, smoking protects from the development of hip OA (OR = 0.543; 95% CI: 0.311 – 0.946; p = 0.031). However, no relationship was found between RA and mtDNA haplogroups.

                Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups play a role in the complex osteoarthritic process.

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