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High systemic bone mineral density increases the risk of incident knee OA and joint space narrowing, but not radiographic progression of existing knee OA: The MOST study
  1. Michael C Nevitt (mnevitt{at}psg.ucsf.edu)
  1. University of California, San Francisco, United States
    1. Yuqing Zhang (yuqing{at}bu.edu)
    1. Boston University Medical Center, United States
      1. M Kassim Javaid (kassim.javaid{at}ndos.ox.ac.uk)
      1. University of Oxford, United Kingdom
        1. Tuhina Neogi (tneogi{at}bu.edu)
        1. Boston University Medical Center, United States
          1. Jeffrey R Curtis (jcurtis{at}uab.edu)
          1. University of Alabama at Birmingham, United States
            1. Jingbo Niu (niujp{at}bu.edu)
            1. Boston University Medical Center, United States
              1. Charles E McCulloch (cmcculloch{at}epi.ucsf.edu)
              1. University of California, San Francisco, United States
                1. Neil Segal (neil-segal{at}uiowa.edu)
                1. University of Iowa, United States
                  1. David T Felson (dfelson{at}bu.edu)
                  1. Boston University Medical Center, United States

                    Abstract

                    Objectives: Previous studies suggest that high systemic bone mineral density (BMD) is associated with incident knee OA defined by osteophytes, but not with joint space narrowing (JSN), and are inconsistent regarding BMD and progression of existing OA. We tested the association of BMD with incident and progressive tibiofemoral OA in a large, prospective study of men and women ages 50-79 with, or at risk for, knee OA.

                    Methods: Baseline and 30-month weight-bearing PA and lateral knee x-rays were scored for K-L grade, JSN and osteophytes. Incident OA was defined as the development of K-L grade ≥2 at follow-up. All knees were classified for increases in grade of JSN and osteophytes from baseline. The association of gender-specific quartiles of baseline BMD with risk of incident and progressive OA was analyzed using logistic regression, adjusting for covariates.

                    Results: The mean age of 1,754 subjects was 63.2 (SD, 7.8) and BMI 29.9 (SD, 5.4). In knees without baseline OA, higher femoral neck and whole body BMD were associated with an increased risk of incident OA and increases in grade of JSN and osteophytes (p < 0.01 for trends); adjusted odds were 2.3 to 2.9-fold greater in the highest vs. the lowest BMD quartiles. In knees with existing OA, progression was not significantly related to BMD.

                    Conclusions: In knees without OA, higher systemic BMD was associated with a greater risk of the onset of JSN and K-L grade ≥2. The role of systemic BMD in early knee OA pathogenesis warrants further investigation.

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