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Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls – a multicenter study using 3.0 Tesla MRI and Lyon Schuss radiography
  1. Marie-Pierre Hellio Le Graverand (helliomp{at}pfizer.com)
  1. Pfizer Global Research & Development, United States
    1. Robert J Buck (robert.j.buck{at}pfizer.com)
    1. Pfizer Global Research & Development, United States
      1. Bradley T Wyman
      1. Pfizer Global Research & Development, United States
        1. Eric Vignon
        1. Universite Claude Bernard, France
          1. Steven A Mazzuca
          1. Inidana University School of Medicine, United States
            1. Kenneth D Brandt
            1. Kansas University Medical Center, United States
              1. Muriel Piperno
              1. Universite Claude Bernard, France
                1. H Cecil Charles
                1. Duke Image Analysis Laboratory, United States
                  1. Martin Hudelmaier (martin.hudelmaier{at}pmu.ac.at)
                  1. Institute of Anatomy & Musculoskeletal Research PMU, Austria
                    1. David J Hunter (djhunter{at}bu.edu)
                    1. Division of Research, New England Baptist Hospital, United States
                      1. Christopher Jackson
                      1. Division of Rheumatology, University of Utah, United States
                        1. Virginia Byers Kraus
                        1. Department of Medicine, Duke University, Rheumatology & Immunology, United States
                          1. Thomas M Link (tmlink{at}radiology.ucsf.edu)
                          1. Department of Radiology, University of California, United States
                            1. Sharmila Majumdar (sharmila.majumdar{at}radiology.ucsf.edu)
                            1. Department of Radiology, University of California, United States
                              1. Pottumarthi V Prasad
                              1. Evanston Northwestern Healthcare, Department of Radiology, United States
                                1. Thomas J Schnitzer
                                1. Department of Physical Medicine and Rehabilitation, Northwestern University Feinberg, School of Med, United States
                                  1. Austin Vaz
                                  1. Section of Rheumatology and Immunology, Arizona Arthritis Center, Department of Medicine, United States
                                    1. Wolfgang Wirth (wirthw{at}in.tum.de)
                                    1. Chondrometrics GmbH, Germany
                                      1. Felix Eckstein (felix.eckstein{at}pmu.ac.at)
                                      1. Institute of Anatomy & Musculoskeletal Research PMU, Austria

                                        Abstract

                                        Objective: Cartilage morphology displays sensitivity to change in osteoarthritis (OA) with quantitative magnetic resonance imaging (qMRI). However, (sub)regional cartilage thickness change at 3.0 Tesla (T) has not been directly compared with radiographic progression of joint space narrowing in OA participants and non-arthritic controls.

                                        Methods: 145 women were imaged at 7 clinical centers: 86 were non-obese and asymptomatic without radiographic OA and 55 were obese with symptomatic and radiographic OA (27 Kellgren Lawrence grade [KLG] 2 and 28 KLG 3). Lyon schuss (LS) and fixed flexion (FF) radiographs were obtained at baseline, 12, and 24 months, and coronal spoiled gradient echo MRI sequences at 3.0T at 6, 12, and 24 months. (Sub)regional femorotibial cartilage thickness and minimum joint space width (mJSW) in the medial femorotibial compartment were measured and the standardized response means (SRMs) determined.

                                        Results: At 6 months, qMRI demonstrated a -3.7% “annualized” change in cartilage thickness (SRM -0.33) in the central medial femorotibial compartment (cMFTC) of KLG3 subjects, but no change in KLG2 subjects. The SRM for mJSW in 12 month LS/FF radiographs of KLG3 participants was -0.68/-0.13 and at 24 months was -0.62/-0.20. The SRM for cMFTC changes measured with qMRI was -0.32 (12 months; -2.0%) and -0.48 (24 months; -2.2%), respectively.

                                        Conclusions: qMRI and LS radiography detected significant change in KLG3 participants at high risk of progression, but not in KLG2 participants, and only small changes in controls. At 12 and 24 months, LS displayed greater, and FF less, sensitivity to change in KLG3 participants than qMRI.

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