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Genetic polymorphisms of the matrix metalloproteinase-3 (MMP-3) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) modulate the development of ankylosing spondylitis
  1. James Cheng-Chung Wei
  1. Department of Medicine, Chung Shan Medical University, Taiwan
    1. Hong-Shen Lee
    1. Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taiwan
      1. Wei-Chiao Chen
      1. Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taiwan
        1. Li-Jie Shiu
        1. Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taiwan
          1. Shun-Fa Yang (ysf{at}csmu.edu.tw)
          1. Institute of Medicine, Chung Shan Medical University, Taiwan
            1. Ruey-Hong Wong (rueyhong{at}csmu.edu.tw)
            1. Department of Public Health, College of Health Care and Management, Chung Shan Medical University, Taiwan

              Abstract

              Objectives: The etiology of ankylosing spondylitis (AS) remains unclear. Inflammation progresses to fibrosis and calcification of the spine and sacroiliac joints in AS development. Fibrosis results from excessive accumulations of extracellular matrix (ECM). ECM turnover depends on the balance between matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). We evaluated the effects of the MMP-3 -1171 and TIMP-1 372 T>C polymorphisms on the modified risk of AS.

              Methods: Genotypes of 241 AS patients and 241 controls were identified by polymerase chain reaction (PCR). Disease activity and functional status were assessed by the Bath Ankylosing Spondylitis Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and the Bath Ankylosing Spondylitis Global (BAS-G) Score.

              Results: MMP-3 6A/6A carriers had a 2.41-fold (95% confidence interval [CI] 1.55, 3.74) increased risk of AS compared with 6A/5A and 5A/5A carriers. TIMP-1 C alleles had a greater risk of AS, but this was not significant (odds ratio [OR] 1.28, 95% CI 0.92, 1.77) . Pairwise analysis of the MMP-3/TIMP-1 alleles revealed that 6A/C (OR 3.23, 95% CI 1.50, 6.95) and 6A/T (OR 2.55, 95% CI 1.17, 5.54) had a significantly greater risk of AS in comparison with the 5A/T alleles. After adjusting for the effects of age, gender, and disease duration, the MMP-3/TIMP-1 5A/T alleles had the lowest BASDAI (p = 0.02), BASFI (p = 0.05), and BAS-G (p = 0.02) among all MMP-3/TIMP-1 alleles.

              Conclusion: Our findings highlighted the importance of the MMP-3 and TIMP-1 genes as crucial elements in AS development.

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