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High frequency of venous thromboembolic events in Churg–Strauss syndrome, Wegener’s granulomatosis and microscopic polyangiitis but not polyarteritis nodosa: a systematic retrospective study on 1130 patients
  1. Yves Allenbach
  1. Cochin Hospital Internal Medicine Department, France
    1. Raphaèle Seror (raphaele.se{at}gmail.com)
    1. Cochin Hospital Internal Medicine Department, France
      1. Christian Pagnoux (christian.pagnoux{at}cch.aphp.fr)
      1. Cochin Hospital Internal Medicine Department, France
        1. Luis Teixeira
        1. Cochin Hospital Internal Medicine Department, France
          1. Phillippe Guilpain
          1. Cochin Hospital Internal Medicine Department, France
            1. Loïc Guillevin
            1. Cochin Hospital Internal Medicine Department, France

              Abstract

              Objective: To determine the frequency and risk factors of venous thromboembolic events (VTE) in Wegener’s granulomatosis (WG), microscopic polyangiitis (MPA), and so far unstudied Churg–Strauss syndrome (CSS) and polyarteritis nodosa (PAN).

              Methods: Retrospective, systematic analysis and comparison between VTE and non-VTE patients’ characteristics among the 1130 WG, MPA, CSS or PAN patients included in the French Vasculitis Study Group cohort.

              Results: During a mean follow-up of 58.4 ± 45.8 months, 83 VTE occurred in 74 (6.5%) patients, with a median vasculitis–VTE-diagnosis interval of 5.8 months [–3 to +156]. VTE occurred in 7/285 (2.5%) PAN, 19/232 (8.2%) CSS, 30/377 (8%) WG, and 18/236 (7.6%) MPA patients. Multivariate analysis retained age, male sex or prior VTE or stroke with motor deficit as being associated with a higher VTE risk. The adjusted odds ratio [95% confidence interval] for VTE was 2.88 [1.27–6.50] for WG, MPA and CSS patients compared to PAN (p= 0.01).

              Conclusion: Our results suggest that, like WG and MPA, CSS patients are at greater risk of VTE, than those with PAN. The reasons for this difference remain to be elucidated.

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