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Is the blood B-cell subset profile diagnostic for Sjögren's syndrome?
  1. Aymeric Binard (aymeric.binard{at}chu-brest.fr)
  1. Brest University Medical School Hospital, France
    1. Laëtitia Le Pottier (laetitia.le.pottier2{at}caramail.com)
    1. Brest University Medical School Hospital, France
      1. Valérie Devauchelle-Pensec (valerie.devauchelle-pensec{at}chu-brest.fr)
      1. Brest University Medical School Hospital, France
        1. Alain Saraux (alain.saraux{at}chu-brest.fr)
        1. Brest University Medical School Hospital, France
          1. Pierre Youinou (youinou{at}univ-brest.fr)
          1. Brest University Medical School Hospital, France
            1. Jacques-Olivier Pers (pers{at}univ-brest.fr)
            1. Brest University Medical School Hospital, France

              Abstract

              Objective: To evaluate the relevance of the blood B-cell subset profile to the diagno-sis of Sjögren’s syndrome (SS).

              Methods: The distribution of mature blood B cells from Bm1 through Bm5 was de-termined in 161 patients, of whom 25 fulfilled the American-European Consensus Group criteria for primary SS (pSS), and 136 served as disease controls.

              Results: The percentage of Bm2 and Bm2' cells was increased in the pSS patients compared with the 54 rheumatoid arthritis (RA) and the 18 systemic lupus erythemato-sus (SLE) patients (p<10-4 for the 2 comparisons). In contrast, those of early Bm5 (eBm5) and Bm5 were decreased in pSS patients, compared with RA, and SLE pa-tients (p<10-4 for the 2 comparisons). The receiver-operating characteristic curves al-lowed for optimizing cut-off value of Bm2+Bm2’ cells at 71.1% for 88.0% sensitivity (Se) and 83.1% specificity (Sp), that of Bm5+Bm5 cells at ≤ 13.5% for 84.0% Se and 83.1% Sp, and consequently that of Bm2+Bm2'/eBm5+Bm5 at ≥ 5 for 88.0% Se and 84.6% Sp.

              Conclusion: Given its presentation as a signature for pSS, relative to RA and SLE, such a distribution of B-cell subsets might provide a useful diagnostic tool.

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