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Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis
  1. Christian Roux (christian.roux{at}cch.aphp.fr)
  1. University Paris-Descartes, France
    1. Jacques Fechtenbaum
    1. University Paris-Descartes, France
      1. Sami Kolta
      1. University Paris-Descartes, France
        1. Giancarlo Isaia
        1. University of Torino, Italy
          1. Jorge B Cannata Andia
          1. University Central des Asturias, Spain
            1. Jean-Pierre Devogelaer
            1. University of Louvain, Belgium

              Abstract

              Objectives: Early osteoporotic fractures have a great impact on the disease progression, the first fracture being a major risk factor for further fractures. Subsequently, the efficacy of antiosteoporotic treatments in the younger women appears of utmost interest. Strontium ranelate is an anti-osteoporotic treatment, simultaneously reducing bone resorption while promoting bone formation. Its efficacy against vertebral fractures is presently assessed in a subset of women aged 50 to 65 years.

              Methods: SOTI was an international, double-blind, placebo-controlled trial, supporting the efficacy of strontium ranelate 2g/day orally in reducing the risk of vertebral fractures in postmenopausal women with osteoporosis and a prevalent vertebral fracture. 353 of these randomized women, aged 50 to 65 years were included in this analysis over 4 years.

              Results: Over 4 years, strontium ranelate significantly reduced the risk of vertebral fracture by 35% (RR=0.65; 95%CI [0.42;0.99], p<0.05). In the strontium ranelate group, the BMD mean change from baseline increased by 15.8% at lumbar spine and 7.1% at femoral neck.

              Conclusion: These data demonstrate a significant vertebral antifracture efficacy of strontium ranelate in young postmenopausal women with severe osteoporosis aged 50 to 65 years and confirms the efficacy of this anti-osteoporotic treatment to prevent vertebral fractures, whatever the age of the patients.

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