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Increased serum levels of B-cell activating factor (BAFF) in subsets of patients with idiopathic inflammatory myopathies
  1. Olga Kryštùfková (okrystufkova{at}email.cz)
  1. Institute of Rheumatology, Prague, Czech Republic
    1. Therese Vallerskog (therese.vallerskog{at}umassmed.edu)
    1. University of Massachusetts Medical School, United States
      1. Sevim Barbasso Helmers (sevim.barbasso{at}ki.se)
      1. Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
        1. Herman Mann (mann{at}revma.cz)
        1. Institute of Rheumatology, Prague, Czech Republic
          1. Ivana Pùtová (puto{at}revma.cz)
          1. Institute of Rheumatology, Prague, Czech Republic
            1. Jaromír Belácek (jaromir.belacek{at}lf1.cuni.cz)
            1. Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University Prague, Czech Republic
              1. Vivianne Malmström (vivianne.malmstrom{at}ki.se)
              1. Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
                1. Christina Trollmo (christina.trollmo{at}roche.com)
                1. Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
                  1. Jiri Vencovsky (venc{at}revma.cz)
                  1. Institute of Rheumatology, Prague, Czech Republic
                    1. Ingrid E Lundberg (ingrid.lundberg{at}ki.se)
                    1. Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

                      Abstract

                      Objective: To investigate serum levels of B-cell activating factor (BAFF) in patients with myositis and correlate these to autoantibody profile, clinical phenotype and treatment.

                      Methods: BAFF levels in sera from 49 patients with dermatomyositis, 44 with polymyositis, 6 with inclusion body myositis and 30 matched controls were measured by enzyme-linked immunosorbent assay (ELISA). Specific autoantibodies were detected by line-blot and western blot assays.

                      Results: Serum levels of BAFF were significantly higher in patients compared to healthy controls (p=0.003). Patients with anti-Jo-1 autoantibodies had higher BAFF levels than control individuals (p<0.003) or patients without any specific autoantibodies (p<0.05). Patients with dermatomyositis had higher BAFF levels compared to polymyositis (p<0.05). Patients with interstitial lung disease (ILD) had higher BAFF levels than patients without ILD (p<0.05) or controls (p<0.01) but this could be explained by presence of anti-Jo-1 autoantibodies. BAFF levels correlated with serum CK (rs=0.365, p=0.0005) but not with CRP levels. A negative correlation of BAFF levels with glucocorticoid daily dose for all patients (rs=-0.292, p=0.003) and with cumulative glucocorticoid doses in early myositis cases (rs=-0.659, p=0.0002) was recorded.

                      Conclusion: Our finding of elevated serum levels of BAFF in myositis patients with described phenotypes together with the correlations between levels of BAFF and CK and a negative correlation with dose of glucocorticoids, indicate that BAFF could be a potential therapeutic target in such cases.

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