Article Text

other Versions

PDF
Changes in hand and generalized bone mineral density in patients with recent-onset rheumatoid arthritis
  1. M Güler-Yüksel (m.yuksel{at}lumc.nl)
  1. Leiden University Medical Center, Netherlands
    1. C F Allaart (c.f.allaart{at}lumc.nl)
    1. LUMC, Netherlands
      1. Y PM Goekoop-Ruiterman (y.p.m.goekoop{at}lumc.nl)
      1. Leiden University Medical Center, Netherlands
        1. J K de Vries-Bouwstra (j.k.de_vries-bouwstra{at}lumc.nl)
        1. Leiden University Medical Center, Netherlands
          1. J HLM van Groenendael (reumarsd{at}hotmail.com)
          1. Franciscus Hospital, Netherlands
            1. C Mallée (mallee{at}kg.nl)
            1. Kennemer Gasthuis, Netherlands
              1. M HW de Bois (m.bois{at}mchaaglanden.nl)
              1. MC Haaglanden, Netherlands
                1. F C Breedveld (f.c.breedveld{at}lumc.nl)
                1. University Hospital Leiden, Netherlands
                  1. B AC Dijkmans (bac.dijkmans{at}vumc.nl)
                  1. VU Medical Center, Netherlands
                    1. W F Lems (wf.lems{at}vumc.nl)
                    1. VU Medicale Center, Netherlands

                      Abstract

                      Objectives: To evaluate changes in bone mineral density (BMD) in the hands, hip and spine after 1 and 2 years of follow-up, in relation to antirheumatic and antiresorptive therapies and disease and demographic variables in patients with recent-onset rheumatoid arthritis (RA).

                      Methods: Changes in BMD measured in the metacarpals 2-4 by digital X-ray radiogrammetry and in the hip and spine by dual energy X-ray absorptiometry were assessed at baseline and after 1 and 2 years of follow-up in 218 recent-onset RA patients from the BeSt study, who received one of four treatment strategies: sequential monotherapy (group 1), step-up combination therapy (group 2), initial combination therapy with tapered high-dose prednisone (group 3), or initial combination therapy with infliximab (group 4).

                      Results: After 1 and 2 years, there was significant BMD loss in all locations, with significantly greater BMD loss in the hands than generalized BMD loss in the hip and spine. Initial combination therapy with prednisone or infliximab were associated with less hand BMD loss compared with initial monotherapy after 1 and 2 years (-0.9 and -1.6%, -0.6 and -1.4%, -1.7 and -3.3%, and -2.6 and -3.6% for group 4-1 after 1 and 2 years, overall p=0.001 and p=0.014, respectively). Progression in erosions was independently associated with increased BMD loss both in the hands and hip after 1 year. The use of bisphosphonates protected only against generalized BMD loss in the hip and spine.

                      Conclusion: The association between joint damage progression and both hand and generalized BMD loss in RA suggests common pathways between these processes, with hand BMD loss occurring earlier in the disease course than generalized BMD loss.

                      Statistics from Altmetric.com

                      Request permissions

                      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.